| Literature DB >> 16784765 |
Christopher O Miles1, Alistair L Wilkins, Allan D Hawkes, Dwayne J Jensen, Janine M Cooney, Kristofer Larsen, Dirk Petersen, Frode Rise, Veronica Beuzenberg, A Lincoln Mackenzie.
Abstract
A cis-isomer of a C(8)-diol ester of okadaic acid (1) was isolated during large-scale purification of pectenotoxins (PTXs) from extracts of Dinophysis acuta collected from the west coast of South Island, New Zealand. The compound was identified by NMR spectroscopic and liquid chromatography-mass spectrometry (LC-MS) studies, and is the first reported cis-isomer of an okadaic acid C(8)-diol-ester identified in Dinophysis. The more abundant trans-C(8)-diol ester of okadaic acid (2) isolated from the same Dinophysis extract was rapidly hydrolyzed to okadaic acid in vitro by the supernatant from green-lipped mussel hepatopancreas.Entities:
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Year: 2006 PMID： 16784765 DOI： 10.1016/j.toxicon.2006.04.018
Source DB: PubMed Journal: Toxicon ISSN： 0041-0101 Impact factor: 3.033