PURPOSE: To utilize dynamic magnetic resonance angiography (MRA) to characterize aortic stiffness (beta) and elastic modulus (Ep) as indexes of wall compliance during the cardiac cycle and determine any influence of different endograft designs or the presence of endoleaks on these indexes. METHODS: Eleven consecutive patients (11 men; median age 74 years, range 63-78) with abdominal aortic aneurysm (AAA) selected for endovascular repair were scanned pre- and postoperatively. Aortic area and diameter changes during the cardiac cycle were determined using dynamic MRA at 4 levels: 3 cm above the renal arteries, between the renal arteries, 1 cm below the renal arteries, and at the level of maximum aneurysm sac diameter. Ep and beta were calculated. Data are presented as median (range); p<0.05 was considered significant. RESULTS: Preoperatively, Ep and beta were significantly higher at the level of the aneurysm sac compared to all other levels (p<0.05). Following EVAR, stiffness increased at this level (p<0.05). After implantation, patients with an Excluder endograft demonstrated Ep and beta measurements at the aneurysm neck that were 94% and 60% higher, respectively, compared to those with a Talent (p<0.05) endograft. The presence of an endoleak had no effect on Ep or beta. CONCLUSION: This study introduces the feasibility of dynamic MRA imaging-based calculations of aortic elastic modulus and stiffness. AAA patients demonstrate increased Ep and beta at the level of the aneurysm sac. EVAR results in increased aneurysm sac Ep and beta. Stent-graft design seems to alter Ep and beta within the aneurysm neck, which may have consequences for endograft durability. The presence of an endoleak does not seem to have an effect on Ep or beta.
PURPOSE: To utilize dynamic magnetic resonance angiography (MRA) to characterize aortic stiffness (beta) and elastic modulus (Ep) as indexes of wall compliance during the cardiac cycle and determine any influence of different endograft designs or the presence of endoleaks on these indexes. METHODS: Eleven consecutive patients (11 men; median age 74 years, range 63-78) with abdominal aortic aneurysm (AAA) selected for endovascular repair were scanned pre- and postoperatively. Aortic area and diameter changes during the cardiac cycle were determined using dynamic MRA at 4 levels: 3 cm above the renal arteries, between the renal arteries, 1 cm below the renal arteries, and at the level of maximum aneurysm sac diameter. Ep and beta were calculated. Data are presented as median (range); p<0.05 was considered significant. RESULTS: Preoperatively, Ep and beta were significantly higher at the level of the aneurysm sac compared to all other levels (p<0.05). Following EVAR, stiffness increased at this level (p<0.05). After implantation, patients with an Excluder endograft demonstrated Ep and beta measurements at the aneurysm neck that were 94% and 60% higher, respectively, compared to those with a Talent (p<0.05) endograft. The presence of an endoleak had no effect on Ep or beta. CONCLUSION: This study introduces the feasibility of dynamic MRA imaging-based calculations of aortic elastic modulus and stiffness. AAA patients demonstrate increased Ep and beta at the level of the aneurysm sac. EVAR results in increased aneurysm sac Ep and beta. Stent-graft design seems to alter Ep and beta within the aneurysm neck, which may have consequences for endograft durability. The presence of an endoleak does not seem to have an effect on Ep or beta.
Authors: Craig J Goergen; Kyla N Barr; Diem T Huynh; Jeffrey R Eastham-Anderson; Gilwoo Choi; Maj Hedehus; Ronald L Dalman; Andrew J Connolly; Charles A Taylor; Philip S Tsao; Joan M Greve Journal: J Magn Reson Imaging Date: 2010-10 Impact factor: 4.813
Authors: Volker Rasche; Alexander Oberhuber; Stephan Trumpp; Axel Bornstedt; Karl-Heinz Orend; Nico Merkle; Wolfgang Rottbauer; Martin Hoffmann Journal: Eur Radiol Date: 2011-02-18 Impact factor: 5.315
Authors: Ahmed Klink; Fabien Hyafil; James Rudd; Peter Faries; Valentin Fuster; Ziad Mallat; Olivier Meilhac; Willem J M Mulder; Jean-Baptiste Michel; Francesco Ramirez; Gert Storm; Robert Thompson; Irene C Turnbull; Jesus Egido; Jose L Martín-Ventura; Carlos Zaragoza; Didier Letourneur; Zahi A Fayad Journal: Nat Rev Cardiol Date: 2011-02-08 Impact factor: 32.419
Authors: Konstantinos G Moulakakis; Spyridon N Mylonas; John Kakisis; Nikolaos P E Kadoglou; Ioannis Papadakis; George S Sfyroeras; Constantine C N Antonopoulos; George Mantas; Ignatios Ikonomidis; Christos D Liapis Journal: Aorta (Stamford) Date: 2015-04-01
Authors: Evan H Phillips; Alexa A Yrineo; Hilary D Schroeder; Katherine E Wilson; Ji-Xin Cheng; Craig J Goergen Journal: Biomed Res Int Date: 2015-05-03 Impact factor: 3.411
Authors: Aneesh K Ramaswamy; Mark Hamilton; Rucha V Joshi; Benjamin P Kline; Rui Li; Pu Wang; Craig J Goergen Journal: ScientificWorldJournal Date: 2013-04-23
Authors: Hector W L de Beaufort; Margherita Coda; Michele Conti; Theodorus M J van Bakel; Foeke J H Nauta; Ettore Lanzarone; Frans L Moll; Joost A van Herwaarden; Ferdinando Auricchio; Santi Trimarchi Journal: PLoS One Date: 2017-10-05 Impact factor: 3.240