Literature DB >> 16783839

The role of the HPA axis in psychiatric disorders and CRF antagonists as potential treatments.

Paul A Keller1, Adam McCluskey, Jody Morgan, Sean M J O'connor.   

Abstract

An overview of the links between the Hypothalamic-Pituitary-Adrenal (HPA) axis and psychiatric disorders is presented. The current treatments are outlined, indicating that they are insufficient to meet the needs of those that suffer from these affective disorders. Therefore, there is an urgent need for the generation of new therapeutics, in particular, against new targets. The association of the corticotrophin releasing factor (CRF) and the HPA axis indicates that CRF antagonists should be beneficial as potential therapeutics.

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Year:  2006        PMID： 16783839     DOI： 10.1002/ardp.200600021

Source DB:  PubMed          Journal:  Arch Pharm (Weinheim)        ISSN： 0365-6233            Impact factor:   3.751


  12 in total

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