| Literature DB >> 16783373 |
Tao Wang1, Xiangbin Zhang, Poonam Bheda, Javier R Revollo, Shin-ichiro Imai, Cynthia Wolberger.
Abstract
Nicotinamide phosphoribosyltransferase (Nampt) synthesizes nicotinamide mononucleotide (NMN) from nicotinamide in a mammalian NAD+ biosynthetic pathway and is required for SirT1 activity in vivo. Nampt has also been presumed to be a cytokine (PBEF) or a hormone (visfatin). The crystal structure of Nampt in the presence and absence of NMN shows that Nampt is a dimeric type II phosphoribosyltransferase and provides insights into the enzymatic mechanism.Entities:
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Year: 2006 PMID： 16783373 DOI： 10.1038/nsmb1114
Source DB: PubMed Journal: Nat Struct Mol Biol ISSN： 1545-9985 Impact factor: 15.369