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Literature DB >> 16783370

Amygdala BDNF signaling is required for consolidation but not encoding of extinction.

Jasmeer P Chhatwal¹, Lisa Stanek-Rattiner, Michael Davis, Kerry J Ressler.

Abstract

Brain-derived neurotrophic factor (BDNF) acting through the tyrosine kinase B receptor (TrkB) is thought to be a critical mediator of learning. As there are no available selective antagonists of TrkB, we used a lentivirus encoding a dominant-negative TrkB (TrkB.t1) to antagonize BDNF signaling during extinction of conditioned fear. Whereas TrkB.t1-infected rats showed normal within-session extinction, their retention of extinction was impaired, suggesting that amygdala TrkB activation is required for the consolidation of stable extinction memories.

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Year: 2006 PMID： 16783370 PMCID： PMC2562628 DOI： 10.1038/nn1718

Source DB: PubMed Journal: Nat Neurosci ISSN： 1097-6256 Impact factor: 24.884

15 in total

1. The role of ventromedial prefrontal cortex in the recovery of extinguished fear.

Authors: G J Quirk; G K Russo; J L Barron; K Lebron
Journal: J Neurosci Date: 2000-08-15 Impact factor: 6.167

2. Consolidation of extinction learning involves transfer from NMDA-independent to NMDA-dependent memory.

Authors: E Santini; R U Muller; G J Quirk
Journal: J Neurosci Date: 2001-11-15 Impact factor: 6.167

3. Extinction of fear-potentiated startle: blockade by infusion of an NMDA antagonist into the amygdala.

Authors: W A Falls; M J Miserendino; M Davis
Journal: J Neurosci Date: 1992-03 Impact factor: 6.167

Review 4. BDNF function in adult synaptic plasticity: the synaptic consolidation hypothesis.

Authors: Clive R Bramham; Elhoucine Messaoudi
Journal: Prog Neurobiol Date: 2005-06 Impact factor: 11.685

5. Neurotrophins and time: different roles for TrkB signaling in hippocampal long-term potentiation.

Authors: H Kang; A A Welcher; D Shelton; E M Schuman
Journal: Neuron Date: 1997-09 Impact factor: 17.173

6. Cognitive enhancers as adjuncts to psychotherapy: use of D-cycloserine in phobic individuals to facilitate extinction of fear.

Authors: Kerry J Ressler; Barbara O Rothbaum; Libby Tannenbaum; Page Anderson; Ken Graap; Elana Zimand; Larry Hodges; Michael Davis
Journal: Arch Gen Psychiatry Date: 2004-11

7. Facilitation of conditioned fear extinction by systemic administration or intra-amygdala infusions of D-cycloserine as assessed with fear-potentiated startle in rats.

Authors: David L Walker; Kerry J Ressler; Kwok-Tung Lu; Michael Davis
Journal: J Neurosci Date: 2002-03-15 Impact factor: 6.167

8. Facilitation of memory for extinction of drug-induced conditioned reward: role of amygdala and acetylcholine.

Authors: Jason P Schroeder; Mark G Packard
Journal: Learn Mem Date: 2004 Sep-Oct Impact factor: 2.460

9. Brain-derived neurotrophic factor and tyrosine kinase receptor B involvement in amygdala-dependent fear conditioning.

Authors: Lisa M Rattiner; Michael Davis; Christopher T French; Kerry J Ressler
Journal: J Neurosci Date: 2004-05-19 Impact factor: 6.167

10. The endogenous cannabinoid system controls extinction of aversive memories.

Authors: Giovanni Marsicano; Carsten T Wotjak; Shahnaz C Azad; Tiziana Bisogno; Gerhard Rammes; Maria Grazia Cascio; Heike Hermann; Jianrong Tang; Clementine Hofmann; Walter Zieglgänsberger; Vincenzo Di Marzo; Beat Lutz
Journal: Nature Date: 2002-08-01 Impact factor: 49.962

110 in total

1. HDAC activity is required for BDNF to increase quantal neurotransmitter release and dendritic spine density in CA1 pyramidal neurons.

Authors: Gaston Calfa; Christopher A Chapleau; Susan Campbell; Takafumi Inoue; Sarah J Morse; Farah D Lubin; Lucas Pozzo-Miller
Journal: Hippocampus Date: 2011-12-07 Impact factor: 3.899

Amygdala BDNF signaling is required for consolidation but not encoding of extinction.

1. The role of ventromedial prefrontal cortex in the recovery of extinguished fear.

2. Consolidation of extinction learning involves transfer from NMDA-independent to NMDA-dependent memory.

3. Extinction of fear-potentiated startle: blockade by infusion of an NMDA antagonist into the amygdala.

Review 4. BDNF function in adult synaptic plasticity: the synaptic consolidation hypothesis.

5. Neurotrophins and time: different roles for TrkB signaling in hippocampal long-term potentiation.

6. Cognitive enhancers as adjuncts to psychotherapy: use of D-cycloserine in phobic individuals to facilitate extinction of fear.

7. Facilitation of conditioned fear extinction by systemic administration or intra-amygdala infusions of D-cycloserine as assessed with fear-potentiated startle in rats.

8. Facilitation of memory for extinction of drug-induced conditioned reward: role of amygdala and acetylcholine.

9. Brain-derived neurotrophic factor and tyrosine kinase receptor B involvement in amygdala-dependent fear conditioning.

10. The endogenous cannabinoid system controls extinction of aversive memories.

1. HDAC activity is required for BDNF to increase quantal neurotransmitter release and dendritic spine density in CA1 pyramidal neurons.

Review 2. Neural and cellular mechanisms of fear and extinction memory formation.

Review 3. Plastic synaptic networks of the amygdala for the acquisition, expression, and extinction of conditioned fear.

4. Hippocampal Mek/Erk signaling mediates extinction of contextual freezing behavior.

Review 5. Fear extinction and BDNF: translating animal models of PTSD to the clinic.

6. BDNF Val⁶⁶Met polymorphism tunes frontolimbic circuitry during affective contextual learning.

7. BDNF deletion or TrkB impairment in amygdala inhibits both appetitive and aversive learning.

Review 8. The Role of BDNF in the Development of Fear Learning.

9. Dissociable roles for the ventromedial prefrontal cortex and amygdala in fear extinction: NR2B contribution.

10. Vagus nerve stimulation promotes generalization of conditioned fear extinction and reduces anxiety in rats.