Literature DB >> 16782344

A flexible approach for the preparation of substituted benzazepines: application to the synthesis of tolvaptan.

Alejandro Cordero-Vargas1, Béatrice Quiclet-Sire, Samir Z Zard.   

Abstract

A practical preparation of benzazepine derivatives using a series of radical and ionic reactions is reported. This approach was applied to the synthesis of tolvaptan, a very promising vasopressin V2 receptor antagonist currently in clinical trials.

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Year:  2006        PMID： 16782344     DOI： 10.1016/j.bmc.2006.05.070

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  4 in total

1.  Stereocontrolled addition of Grignard reagents to oxa-bridged benzazepines: highly efficient synthesis of functionalized benzazepine scaffolds.

Authors:  Yuewei Zhang; Qingqing Bao; Ning Zhang; Shuohang Wang; Xue Yu
Journal:  RSC Adv       Date:  2020-11-17       Impact factor: 4.036

2.  Divergent synthesis of benzazepines and bridged polycycloalkanones via dearomative rearrangement.

Authors:  Qiu Shi; Zhehui Liao; Zhili Liu; Jiajia Wen; Chenguang Li; Jiamin He; Jiazhen Deng; Shan Cen; Tongxiang Cao; Jinming Zhou; Shifa Zhu
Journal:  Nat Commun       Date:  2022-07-29       Impact factor: 17.694

3.  Continuous-Flow Synthesis of Nitro-o-xylenes: Process Optimization, Impurity Study and Extension to Analogues.

Authors:  Qiao Song; Xiangui Lei; Sheng Yang; Sheng Wang; Jianhui Wang; Jiujun Chen; Yong Xiang; Qingwu Huang; Zhouyu Wang
Journal:  Molecules       Date:  2022-08-12       Impact factor: 4.927

4.  Modular Entry to Functionalized Tetrahydrobenzo[b]azepines via the Palladium/Norbornene Cooperative Catalysis Enabled by a C7-Modified Norbornene.

Authors:  Xin Liu; Jianchun Wang; Guangbin Dong
Journal:  J Am Chem Soc       Date:  2021-06-23       Impact factor: 16.383
  4 in total

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