CONTEXT: The incidence of tendon injuries and tendinopathy has risen substantially in the past decades. OBJECTIVE: To assess the noninferiority of therapy based on the homeopathic preparation Traumeel S ointment (Heel GmbH, Baden-Baden, Germany) compared with treatment based on diclofenac 1% gel in patients with tendinopathies of varying etiology. DESIGN: Nonrandomized, observational study. SETTING: Ninety-five homeopathy and conventional medical practices in Germany. PATIENTS: Three hundred fifty-seven patients aged 18 to 93 years with tendinopathy of varying etiology based on excessive tendon load rather than inflammation. INTERVENTIONS: Traumeel S ointment or diclofenac 1% gel for a maximum of 28 days. MAIN OUTCOME MEASURES: Efficacy was measured on a four-degree scale on pain-related variables, on variables related to motility, and on overall treatment outcome. Tolerability was monitored as adverse events. Compliance was assessed by practitioner and patient on a four-degree scale. RESULTS: The patients groups were comparable at baseline. The changes in summary score of all pain-related variables were -5.3 +/- 2.7 (all values means +/- SD) in the Traumeel group and -5.0 +/- 2.7 in the control group. Changes for all motility-related variables were -4.2 +/- 3.8 with Traumeel and -3.7 +/- 3.4 with control therapy. The summary scores for all clinical variables were reduced by -9.5 +/- 5.7 with Traumeel therapy and by -8.7 +/- 5.4 with diclofenac-based treatment. Homeopathic therapy was noninferior to diclofenac therapy on all variables. For motility-related variables, there was a trend toward superiority of Traumeel. Treatments were well tolerated with no treatment-related adverse events. CONCLUSIONS: The results suggest that Traumeel ointment is an effective alternative to nonsteroidal antiinflammatory drugs therapy for the acute symptomatic treatment of patients with tendinopathy.
CONTEXT: The incidence of tendon injuries and tendinopathy has risen substantially in the past decades. OBJECTIVE: To assess the noninferiority of therapy based on the homeopathic preparation Traumeel S ointment (Heel GmbH, Baden-Baden, Germany) compared with treatment based on diclofenac 1% gel in patients with tendinopathies of varying etiology. DESIGN: Nonrandomized, observational study. SETTING: Ninety-five homeopathy and conventional medical practices in Germany. PATIENTS: Three hundred fifty-seven patients aged 18 to 93 years with tendinopathy of varying etiology based on excessive tendon load rather than inflammation. INTERVENTIONS: Traumeel S ointment or diclofenac 1% gel for a maximum of 28 days. MAIN OUTCOME MEASURES: Efficacy was measured on a four-degree scale on pain-related variables, on variables related to motility, and on overall treatment outcome. Tolerability was monitored as adverse events. Compliance was assessed by practitioner and patient on a four-degree scale. RESULTS: The patients groups were comparable at baseline. The changes in summary score of all pain-related variables were -5.3 +/- 2.7 (all values means +/- SD) in the Traumeel group and -5.0 +/- 2.7 in the control group. Changes for all motility-related variables were -4.2 +/- 3.8 with Traumeel and -3.7 +/- 3.4 with control therapy. The summary scores for all clinical variables were reduced by -9.5 +/- 5.7 with Traumeel therapy and by -8.7 +/- 5.4 with diclofenac-based treatment. Homeopathic therapy was noninferior to diclofenac therapy on all variables. For motility-related variables, there was a trend toward superiority of Traumeel. Treatments were well tolerated with no treatment-related adverse events. CONCLUSIONS: The results suggest that Traumeel ointment is an effective alternative to nonsteroidal antiinflammatory drugs therapy for the acute symptomatic treatment of patients with tendinopathy.
Authors: Shepherd R Singer; Michal Amit-Kohn; Samuel Weiss; Jonathan Rosenblum; Guy Maoz; Noah Samuels; Esther Lukasiewicz; Laurence Freedman; Ora Paltiel; Menachem Itzchaki; Meir Niska; Menachem Oberbaum Journal: BMC Clin Pharmacol Date: 2010-04-12
Authors: Gian Nicola Bisciotti; Piero Volpi; Maurizio Amato; Giampietro Alberti; Francesco Allegra; Alessandro Aprato; Matteo Artina; Alessio Auci; Corrado Bait; Gian Matteo Bastieri; Luca Balzarini; Andrea Belli; Gianandrea Bellini; Pierfrancesco Bettinsoli; Alessandro Bisciotti; Andrea Bisciotti; Stefano Bona; Lorenzo Brambilla; Marco Bresciani; Michele Buffoli; Filippo Calanna; Gian Luigi Canata; Davide Cardinali; Giulia Carimati; Gabriella Cassaghi; Enrico Cautero; Emanuele Cena; Barbara Corradini; Alessandro Corsini; Cristina D'Agostino; Massimo De Donato; Giacomo Delle Rose; Francesco Di Marzo; Francesco Di Pietto; Drapchind Enrica; Cristiano Eirale; Luigi Febbrari; Paolo Ferrua; Andrea Foglia; Alberto Galbiati; Alberto Gheza; Carlo Giammattei; Francesco Masia; Gianluca Melegati; Biagio Moretti; Lorenzo Moretti; Roberto Niccolai; Antonio Orgiani; Claudio Orizio; Andrea Pantalone; Federica Parra; Paolo Patroni; Maria Teresa Pereira Ruiz; Marzio Perri; Stefano Petrillo; Luca Pulici; Alessandro Quaglia; Luca Ricciotti; Francesco Rosa; Nicola Sasso; Claudio Sprenger; Chiara Tarantola; Fabio Gianpaolo Tenconi; Fabio Tosi; Michele Trainini; Agostino Tucciarone; Ali Yekdah; Zarko Vuckovic; Raul Zini; Karim Chamari Journal: BMJ Open Sport Exerc Med Date: 2018-05-24