Literature DB >> 16781339

The relationship between temporomandibular joint synovitis and adhesions: pathogenic mechanisms and clinical implications for surgical management.

Howard A Israel1, Claude-Jean Langevin, Michael D Singer, David A Behrman.   

Abstract

PURPOSE: The purpose of this investigation was to determine the relationship between arthroscopically diagnosed synovitis and adhesions in a population of patients with significant limitation of mandibular opening and temporomandibular joint pain. PATIENTS AND METHODS: Temporomandibular joint arthroscopy was performed on 126 joints in 80 patients (female:male = 5.7:1; mean age = 35.5 years; mean duration of symptoms = 50 months). All patients were diagnosed with severe temporomandibular joint disease recalcitrant to conservative therapy. Each joint was evaluated arthroscopically for the presence of synovitis and adhesions. Chi-squared analysis was performed to determine if there was a significant relationship between the presence of synovitis and adhesions.
RESULTS: Diagnostic arthroscopic examination showed the following: no synovitis and no adhesions in 18/126 joints (14%), no synovitis with adhesions present in 33/126 joints (26%), synovitis with no adhesions in 13/126 joints (10%), and synovitis and adhesions present in 62/126 joints (49%). Statistical analysis showed a significant relationship between arthroscopically diagnosed synovitis and adhesions.
CONCLUSION: Synovitis and adhesions are commonly present in the temporomandibular joints of patients requiring arthroscopic surgery due to painful limitation of mandibular movement. Excessive mechanical stress on the temporomandibular joint leads to maladaptive responses in the articular and synovial tissues, ultimately leading to synovitis, osteoarthritis and the formation of adhesions. An understanding of the pathogenic mechanisms that lead to synovitis, osteoarthritis and adhesions has important clinical implications for the nonsurgical as well as surgical management of patients suffering from these disorders.

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Year:  2006        PMID: 16781339     DOI: 10.1016/j.joms.2006.03.012

Source DB:  PubMed          Journal:  J Oral Maxillofac Surg        ISSN: 0278-2391            Impact factor:   1.895


  9 in total

1.  Arthrocentesis for the treatment of internal derangement of the temporomandibular joint.

Authors:  Arati S Neeli; Meenaxi Umarani; S M Kotrashetti; Shridhar Baliga
Journal:  J Maxillofac Oral Surg       Date:  2011-02-17

2.  Evaluation of efficacy of arthrocentesis (with normal saline) with or without sodium hyaluronate in treatment of internal derangement of TMJ - A prospective randomized study in 20 patients.

Authors:  Aditi Sharma; Amar Singh Rana; Gaurav Jain; Puneet Kalra; Deepak Gupta; Siddharth Sharma
Journal:  J Oral Biol Craniofac Res       Date:  2013-10-15

Review 3.  Temporomandibular joint pain and dysfunction.

Authors:  Kathleen Herb; Sung Cho; Marlind Alan Stiles
Journal:  Curr Pain Headache Rep       Date:  2006-12

4.  Arthrocentesis and temporomandibular joint disorders: clinical and radiological results of a prospective study.

Authors:  Giacomo De Riu; Mirella Stimolo; Silvio Mario Meloni; Damiano Soma; Milena Pisano; Salvatore Sembronio; Antonio Tullio
Journal:  Int J Dent       Date:  2013-11-11

Review 5.  Potential Role of Rebamipide in Osteoclast Differentiation and Mandibular Condylar Cartilage Homeostasis.

Authors:  Takashi Izawa; Islamy Rahma Hutami; Eiji Tanaka
Journal:  Curr Rheumatol Rev       Date:  2018-04-20

6.  Two-photon fluorescence and second harmonic generation characterization of extracellular matrix remodeling in post-injury murine temporomandibular joint osteoarthritis.

Authors:  David A Reed; Mamoru Yotsuya; Polina Gubareva; Peter T Toth; Andrew Bertagna
Journal:  PLoS One       Date:  2019-03-21       Impact factor: 3.240

Review 7.  Osteoimmunology of Oral and Maxillofacial Diseases: Translational Applications Based on Biological Mechanisms.

Authors:  Carla Alvarez; Gustavo Monasterio; Franco Cavalla; Luis A Córdova; Marcela Hernández; Dominique Heymann; Gustavo P Garlet; Timo Sorsa; Pirjo Pärnänen; Hsi-Ming Lee; Lorne M Golub; Rolando Vernal; Alpdogan Kantarci
Journal:  Front Immunol       Date:  2019-07-18       Impact factor: 8.786

8.  Mechanical Loading Disrupts Focal Adhesion Kinase Activation in Mandibular Fibrochondrocytes During Murine Temporomandibular Joint Osteoarthritis.

Authors:  David A Reed; Yan Zhao; Michael Han; Louis G Mercuri; Michael Miloro
Journal:  J Oral Maxillofac Surg       Date:  2021-05-13       Impact factor: 2.136

9.  Gene Expression Profiling of IL-17A-Treated Synovial Fibroblasts from the Human Temporomandibular Joint.

Authors:  Toshio Hattori; Naomi Ogura; Miwa Akutsu; Mutsumi Kawashima; Suguru Watanabe; Ko Ito; Toshirou Kondoh
Journal:  Mediators Inflamm       Date:  2015-12-29       Impact factor: 4.711

  9 in total

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