Literature DB >> 16781309

Acne in recipients of renal transplantation treated with sirolimus: clinical, microbiologic, histologic, therapeutic, and pathogenic aspects.

Emmanuel Mahé1, Emmanuel Morelon, Sophie Lechaton, Jean-Christophe Drappier, Yves de Prost, Henri Kreis, Christine Bodemer.   

Abstract

We evaluated the clinical characteristics of sirolimus-induced acne in 80 recipients of renal transplantation. It developed in 36 of 48 (75%) men and 2 of 32 (6%) women. Lesion locations and clinical, bacteriologic, and histologic features differentiated sirolimus-induced acne from acne vulgaris, but therapeutic management was similar. The main limitation for this study was the absence of a control group without sirolimus. Epidermal growth factor inhibition by sirolimus is a plausible explanation for this acne.

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Year:  2006        PMID： 16781309     DOI： 10.1016/j.jaad.2005.11.1072

Source DB:  PubMed          Journal:  J Am Acad Dermatol        ISSN： 0190-9622            Impact factor:   11.527


  5 in total

1.  Extended follow-up of methotrexate-free immunosuppression using sirolimus and tacrolimus in related and unrelated donor peripheral blood stem cell transplantation.

Authors:  Corey Cutler; Shuli Li; Vincent T Ho; John Koreth; Edwin Alyea; Robert J Soiffer; Joseph H Antin
Journal:  Blood       Date:  2007-04-01       Impact factor: 22.113

2.  Palmoplantar peeling secondary to sirolimus therapy.

Authors:  L S Liu; J M McNiff; O R Colegio
Journal:  Am J Transplant       Date:  2013-11-13       Impact factor: 8.086

3.  A retrospective analysis of dermatological lesions in kidney transplant patients.

Authors:  Michela Castello; Marilena Gregorini; Teresa Rampino; Francesca Bosio; Giulia Bedino; Giovanni Piotti; Grazia Soccio; Pasquale Esposito; Catherine Klersy; Massimo Abelli; Giovanni Borroni; Antonio Dal Canton
Journal:  Indian J Med Res       Date:  2013-06       Impact factor: 2.375

4.  Dermatological adverse events associated with use of oral mechanistic target of rapamycin inhibitors in a cohort of individuals with tuberous sclerosis complex.

Authors:  D J Pithadia; A M Treichel; A M Jones; P Julien-Williams; T Machado; J Moss; T N Darling
Journal:  Br J Dermatol       Date:  2020-05-26       Impact factor: 11.113

5.  Sirolimus as Long-term Graft-versus-host-disease Prophylaxis in Haploidentical Hematopoietic Stem Cell Transplant Recipients for Non-malignant Disorders is Associated with High Incidence of Acneiform Lesions.

Authors:  Aditi Chakrbarti; Sarita Rani Jaiswal; Suparno Chakrabarti
Journal:  Indian J Dermatol       Date:  2015 Nov-Dec       Impact factor: 1.494
  5 in total

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