| Literature DB >> 16781148 |
Byul Nae Yoo1, Hea Ok Kim, Hyung Ryong Moon, Su Kyung Seol, Sung Key Jang, Kang Man Lee, Lak Shin Jeong.
Abstract
On the basis of potent anti-HCV activity of 2'-C-methyladenosine, novel 2'-C-hydroxymethyladenosine analogues 2a-c were synthesized from d-ribose in order to lead to favorable interaction with HCV polymerase. Among compounds tested, adenosine derivative 2a exhibited potent anti-HCV activity, indicating that the hydroxyl group of 2'-C-hydroxymethyl substituent led to favorable interaction with HCV polymerase.Entities:
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Year: 2006 PMID： 16781148 DOI： 10.1016/j.bmcl.2006.05.089
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823