| Literature DB >> 16780947 |
Shuji Tohda1, Taku Sato, Hanae Kogoshi, Lu Fu, Seiji Sakano, Nobuo Nara.
Abstract
A novel lymphoma cell line, designated TMD8 was established from cells of a patient with diffuse large B-cell lymphoma. TMD8 cells expressed HES1 mRNA, suggesting constitutive activation of Notch signaling. TMD8 cells expressed normal-sized Notch1 protein, and showed no mutations in the NOTCH1 gene. Cell growth was suppressed by gamma-secretase inhibitors (GSI). It was reported that GSI suppressed growth of T-cell acute lymphoblastic leukemia (T-ALL) cell lines, which frequently had NOTCH1 mutations. In addition to T-ALL, TMD8 is another unique cell line sensitive to GSI, and is useful to study effects of GSI in molecular targeting therapy.Entities:
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Year: 2006 PMID： 16780947 DOI： 10.1016/j.leukres.2006.05.003
Source DB: PubMed Journal: Leuk Res ISSN： 0145-2126 Impact factor: 3.156