Bin Liu1, Ren-Bing Shi. 1. School of Chinese Pharmacology, Beijing University of Traditional Chinese Medicine, Beijing 100102, China. liubinyn67@163.com
Abstract
OBJECTIVE: To study the chemical constituents of the alkaloid fraction of Kushen decoction. METHOD: Constituents were isolated by different kinds of column chromatography and their structures were elucidated with spectral methods. RESULT: Eight compounds were isolated and identified as matrine (I), sophoridine (II), sophocarpine (III), sophoramine (IV), oxymatrine (V), oxysophocarpine (VI), aloperine (VII) and sparteine (VIII). CONCLUSION: All these compounds were isolated from Kushen decoction for the first time. Aloperine was found firstly in Sophora flavescens, or Scutellaria baicalensis, or Rehmannia glutinosa which constituted Kushen decoction.
OBJECTIVE: To study the chemical constituents of the alkaloid fraction of Kushen decoction. METHOD: Constituents were isolated by different kinds of column chromatography and their structures were elucidated with spectral methods. RESULT: Eight compounds were isolated and identified as matrine (I), sophoridine (II), sophocarpine (III), sophoramine (IV), oxymatrine (V), oxysophocarpine (VI), aloperine (VII) and sparteine (VIII). CONCLUSION: All these compounds were isolated from Kushen decoction for the first time. Aloperine was found firstly in Sophora flavescens, or Scutellaria baicalensis, or Rehmannia glutinosa which constituted Kushen decoction.