| Literature DB >> 16777158 |
Young-Won Chin1, William P Jones, Qiuwen Mi, Ismail Rachman, Soedarsono Riswan, Leonardus B S Kardono, Hee-Byung Chai, Norman R Farnsworth, Geoffrey A Cordell, Steven M Swanson, John M Cassady, A Douglas Kinghorn.
Abstract
Three clerodane diterpenoids, premnones A-C (1-3), were isolated from a chloroform-soluble fraction of Premna tomentosa along with four known flavonoids and three known triterpenoids. Among these isolates, premnones A-C exhibited cytotoxic activity when evaluated against a small panel of tumor cell lines. However, premnone A was found to be inactive when evaluated in a follow-up in vivo hollow fiber assay at the highest dose tested (50mg/kg), using LNCaP, Lu1, and MCF-7 cells.Entities:
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Year: 2006 PMID： 16777158 DOI： 10.1016/j.phytochem.2006.04.015
Source DB: PubMed Journal: Phytochemistry ISSN： 0031-9422 Impact factor: 4.072