Literature DB >> 16775811

Inhibitory activity on HIV-1 reverse transcriptase and integrase of a carmalol derivative from a brown Alga, Ishige okamurae.

M-J Ahn1, K-D Yoon, C Y Kim, J H Kim, C-G Shin, J Kim.   

Abstract

The bioassay-directed isolation of a marine brown alga, Ishige okamurae, afforded a carmalol derivative, diphlorethohydroxycarmalol. This compound exhibited inhibitory effects on HIV-1 reverse transcriptase and integrase with IC(50) values of 9.1 microM and 25.2 microM, respectively. However, diphlorethohydroxycarmalol did not show an inhibitory activity against HIV-1 protease. Moreover, diphlorethohydroxycarmalol nonaacetate obtained by acetylation and fucosterol failed to show any inhibitory activity against these viral enzymes.

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Year:  2006        PMID： 16775811     DOI： 10.1002/ptr.1939

Source DB:  PubMed          Journal:  Phytother Res        ISSN： 0951-418X            Impact factor:   5.878


  12 in total

Review 1.  Role of Marine Natural Products in the Genesis of Antiviral Agents.

Authors:  Vedanjali Gogineni; Raymond F Schinazi; Mark T Hamann
Journal:  Chem Rev       Date:  2015-08-28       Impact factor: 60.622

Review 2.  Bioactive Properties of Marine Phenolics.

Authors:  Raquel Mateos; José Ricardo Pérez-Correa; Herminia Domínguez
Journal:  Mar Drugs       Date:  2020-09-30       Impact factor: 5.118

3.  Viral inhibitors derived from macroalgae, microalgae, and cyanobacteria: A review of antiviral potential throughout pathogenesis.

Authors:  Daman Reynolds; Michael Huesemann; Scott Edmundson; Amy Sims; Brett Hurst; Sherry Cady; Nathan Beirne; Jacob Freeman; Adam Berger; Song Gao
Journal:  Algal Res       Date:  2021-05-18       Impact factor: 4.401

Review 4.  Potential anti-HIV agents from marine resources: an overview.

Authors:  Thanh-Sang Vo; Se-Kwon Kim
Journal:  Mar Drugs       Date:  2010-11-29       Impact factor: 5.118

5.  Sargassum coreanum extract alleviates hyperglycemia and improves insulin resistance in db/db diabetic mice.

Authors:  Mi Hwa Park; Young Hwa Nam; Ji-Sook Han
Journal:  Nutr Res Pract       Date:  2015-06-19       Impact factor: 1.926

6.  Anti-inflammatory effect of supercritical extract and its constituents from Ishige okamurae.

Authors:  Eun-Yi Ko; Weon-Jong Yoon; Hae-Won Lee; Soo-Jin Heo; Young-Hwan Ko; I P Shanura Fernando; Kichul Cho; Chi-Heon Lee; Sung-Pyo Hur; Su-Hyeon Cho; Ginnae Ahn; Daekyung Kim; Kil-Nam Kim
Journal:  EXCLI J       Date:  2016-06-28       Impact factor: 4.068

7.  Diphlorethohydroxycarmalol Attenuates Fine Particulate Matter-Induced Subcellular Skin Dysfunction.

Authors:  Ao Xuan Zhen; Mei Jing Piao; Yu Jae Hyun; Kyoung Ah Kang; Pincha Devage Sameera Madushan Fernando; Suk Ju Cho; Mee Jung Ahn; Jin Won Hyun
Journal:  Mar Drugs       Date:  2019-02-01       Impact factor: 5.118

8.  Protective Effect of Diphlorethohydroxycarmalol against Ultraviolet B Radiation-Induced DNA Damage by Inducing the Nucleotide Excision Repair System in HaCaT Human Keratinocytes.

Authors:  Mei Jing Piao; Susara Ruwan Kumara Madduma Hewage; Xia Han; Kyoung Ah Kang; Hee Kyoung Kang; Nam Ho Lee; Jin Won Hyun
Journal:  Mar Drugs       Date:  2015-09-02       Impact factor: 5.118

Review 9.  Marine Algae Metabolites as Promising Therapeutics for the Prevention and Treatment of HIV/AIDS.

Authors:  Natalya N Besednova; Tatyana N Zvyagintseva; Tatyana A Kuznetsova; Ilona D Makarenkova; Tatyana P Smolina; Ludmila N Fedyanina; Sergey P Kryzhanovsky; Tatyana S Zaporozhets
Journal:  Metabolites       Date:  2019-05-02

10.  Diphlorethohydroxycarmalol Isolated from Ishige okamurae Represses High Glucose-Induced Angiogenesis In Vitro and In Vivo.

Authors:  K H N Fernando; Hye-Won Yang; Yunfei Jiang; You-Jin Jeon; BoMi Ryu
Journal:  Mar Drugs       Date:  2018-10-10       Impact factor: 5.118
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