B Kraft1, S Leroy, M Schweizer, W Junginger, R Bittner. 1. Abteilung für Allgemein- und Visceralchirurgie, Marienhospital, Böheimstrasse 37, 70199 Stuttgart. barbarakraft@vinzenz.de
Abstract
BACKGROUND: The goal of our study was to evaluate the morphine-sparing effect of nonsteroidal anti-inflammatory drugs (NSAIDs) following both conventional and laparoscopic colon surgery. MATERIALS AND METHODS: In this prospective, randomized clinical trial, 180 patients were assigned to three groups. Two groups received either paracetamol or parecoxib/valdecoxib in addition to piritramid via patient-controlled or nurse-controlled analgesia pump. Patients in the control group received piritramid only. The total piritramid consumption during hospital stay was recorded. RESULTS:Total opioid consumption was significantly lower in the two groups who received NSAIDs. Comparing conventional and laparoscopic surgery, the latter group had much lower opioid consumption. CONCLUSION: The use of NSAIDs following colon surgery significantly reduces postoperative opioid consumption.
RCT Entities:
BACKGROUND: The goal of our study was to evaluate the morphine-sparing effect of nonsteroidal anti-inflammatory drugs (NSAIDs) following both conventional and laparoscopic colon surgery. MATERIALS AND METHODS: In this prospective, randomized clinical trial, 180 patients were assigned to three groups. Two groups received either paracetamol or parecoxib/valdecoxib in addition to piritramid via patient-controlled or nurse-controlled analgesia pump. Patients in the control group received piritramid only. The total piritramid consumption during hospital stay was recorded. RESULTS: Total opioid consumption was significantly lower in the two groups who received NSAIDs. Comparing conventional and laparoscopic surgery, the latter group had much lower opioid consumption. CONCLUSION: The use of NSAIDs following colon surgery significantly reduces postoperative opioid consumption.
Authors: Nancy A Nussmeier; Andrew A Whelton; Mark T Brown; Girish P Joshi; Richard M Langford; Neil K Singla; Mark E Boye; Kenneth M Verburg Journal: Anesthesiology Date: 2006-03 Impact factor: 7.892
Authors: Jens Dingemann; Joachim F Kuebler; Mathias Wolters; Mirja von Kampen; Wilhelm A Osthaus; Benno M Ure; Marc Reismann Journal: World J Urol Date: 2009-06-30 Impact factor: 4.226