STUDY OBJECTIVES: To compare the effect of noninvasive mechanical ventilation (NIV) in severely acidotic with mildly acidotic patients with acute hypercapnic chronic obstructive lung disease (COPD). DESIGN: Comparison of NIV in consecutively enrolled patients with acute hypercapnic COPD with mild (pH 7.25-7.35) or severe (pH<7.25) acidosis on time to normalise pH and improve PaCO(2), duration of NIV treatment, length of stay in hospital and survival. Results (meadian (IQR)): Twenty-nine patients had 36 episodes of acute hypercapnic respiratory failure: Seventeen with pH<7.25 and 19 with pH 7.25-7.34. Compared with the mildly acidotic group, the severely acidotic group took a similar length of time for pH to normalise and PaCO(2) improve (12 (6-34) vs 12 (4-28)h, respectively, P=0.42), with similar duration of NIV treatment (60 (35-96) vs 68 (36-48)h, respectively, P=0.25) and hospital length of stay (8 (7-18) vs 9 (5-17) days, respectively, P=0.61). Overall survival was 89%, with 95% in the mild and 82% in the severely acidotic groups. CONCLUSIONS: Noninvasive ventilation is effective in the treatment of patients with severe acidosis due to acute hypercapnic COPD.
STUDY OBJECTIVES: To compare the effect of noninvasive mechanical ventilation (NIV) in severely acidotic with mildly acidotic patients with acute hypercapnic chronic obstructive lung disease (COPD). DESIGN: Comparison of NIV in consecutively enrolled patients with acute hypercapnic COPD with mild (pH 7.25-7.35) or severe (pH<7.25) acidosis on time to normalise pH and improve PaCO(2), duration of NIV treatment, length of stay in hospital and survival. Results (meadian (IQR)): Twenty-nine patients had 36 episodes of acute hypercapnic respiratory failure: Seventeen with pH<7.25 and 19 with pH 7.25-7.34. Compared with the mildly acidotic group, the severely acidotic group took a similar length of time for pH to normalise and PaCO(2) improve (12 (6-34) vs 12 (4-28)h, respectively, P=0.42), with similar duration of NIV treatment (60 (35-96) vs 68 (36-48)h, respectively, P=0.25) and hospital length of stay (8 (7-18) vs 9 (5-17) days, respectively, P=0.61). Overall survival was 89%, with 95% in the mild and 82% in the severely acidotic groups. CONCLUSIONS: Noninvasive ventilation is effective in the treatment of patients with severe acidosis due to acute hypercapnic COPD.
Authors: Ciara E Keogh; Carsten C Scholz; Javier Rodriguez; Andrew C Selfridge; Alexander von Kriegsheim; Eoin P Cummins Journal: J Biol Chem Date: 2017-05-15 Impact factor: 5.157
Authors: Kathryn M Oliver; Colin R Lenihan; Ulrike Bruning; Alex Cheong; John G Laffey; Paul McLoughlin; Cormac T Taylor; Eoin P Cummins Journal: J Biol Chem Date: 2012-03-06 Impact factor: 5.157
Authors: Juan F Masa; Isabel Utrabo; Javier Gomez de Terreros; Myriam Aburto; Cristóbal Esteban; Enric Prats; Belén Núñez; Ángel Ortega-González; Luis Jara-Palomares; M Jesus Martin-Vicente; Eva Farrero; Alicia Binimelis; Ernest Sala; José C Serrano-Rebollo; Emilia Barrot; Raquel Sánchez-Oro-Gomez; Ramón Fernández-Álvarez; Francisco Rodríguez-Jerez; Javier Sayas; Pedro Benavides; Raquel Català; Francisco J Rivas; Carlos J Egea; Antonio Antón; Patricia Peñacoba; Ana Santiago-Recuerda; M A Gómez-Mendieta; Lidia Méndez; José J Cebrian; Juan A Piña; Enrique Zamora; Gonzalo Segrelles Journal: BMC Pulm Med Date: 2016-07-07 Impact factor: 3.317