Literature DB >> 16774258

Studies toward soraphen A: an aldol-metathesis avenue to the macrocyclic framework.

Guillaume Vincent1, Darren J Mansfield, Jean-Pierre Vors, Marco A Ciufolini.   

Abstract

[reaction: see text] We describe a convergent approach to soraphen A, 1, that involves coupling of two fragments by an aldol condensation-olefin metathesis sequence. This route permits rapid access to congeners of 1.

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Year:  2006        PMID： 16774258     DOI： 10.1021/ol060882s

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  4 in total

1.  Synthesis of C11-Desmethoxy Soraphen A1α: A natural product analog that inhibits acetyl-CoA carboxylase.

Authors:  Daniel P Canterbury; Kristen E N Scott; Ozora Kubo; Rolf Jansen; John L Cleveland; Glenn C Micalizio
Journal:  ACS Med Chem Lett       Date:  2013-12-12       Impact factor: 4.345

2.  Enantioselective syntheses of syn- and anti-β-hydroxyallylsilanes via allene hydroboration-aldehyde allylboration reactions.

Authors:  Ming Chen; William R Roush
Journal:  Org Lett       Date:  2011-03-16       Impact factor: 6.005

3.  Total Synthesis of the Acetyl CoA Carboxylase Inhibitor Soraphen A: Asymmetric Tsuji Reduction Enables Successive Olefin Metathesis.

Authors:  Tabitha T Schempp; Michael J Krische
Journal:  J Am Chem Soc       Date:  2022-01-10       Impact factor: 15.419

4.  Asymmetric total synthesis of soraphen A: a flexible alkyne strategy.

Authors:  Barry M Trost; Joshua D Sieber; Wei Qian; Rajiv Dhawan; Zachary T Ball
Journal:  Angew Chem Int Ed Engl       Date:  2009       Impact factor: 15.336
  4 in total

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