BACKGROUND: The most efficient approach for studies examining the incidence of dementia involves a brief screening instrument to identify participants for more extensive testing to identify cognitive impairment. The modified mini-mental state examination (3MS) is commonly used as this initial screen in such two-stage designs, however its properties for this role require further study. PURPOSE: We use data from the Women's Health Initiative Memory Study to contrast design options in two-stage designs. METHODS: This trial enrolled 7251 participants with nine or more years of education who were aged 65-79 and followed an average of four to five years. Logistic regression was used to examine the case yields at varying two-stage 3MS cutpoints. The efficiency of using different examination schedules and restricting enrollment to higher risk women was examined. RESULTS: Probable dementia is associated with marked decline in 3MS scores. The percentages of women classified with probable dementia ranged from 7.95% (3MS 85-88) to 50.0% (3MS < 70). The numbers [95% confidence interval] of enrolled women necessary to detect one case of probable dementia (four-year follow-up) for baseline 3MS scores of 100, 95, 90 and 85 were estimated as 1477 [389, 5618], 253 [134, 481], 53 [34, 85], and 14 [9, 23], respectively. Compared to annual testing, administration every two years increased the number of required enrollees by 11%, but decreased the number of test administrations by 46%. LIMITATIONS: Our findings are influenced by the characteristics of our study group, its rates of retention, and the study protocol, and may not fully generalize to other settings. CONCLUSIONS: The 3MS can serve as an efficient basis for two-stage study designs and a cutpoint of < or = 88 is reasonable for populations with similar characteristics. Studies may improve efficiency by using the 3MS during screening to eliminate women with low risk for dementia and by conducting testing every two years.
BACKGROUND: The most efficient approach for studies examining the incidence of dementia involves a brief screening instrument to identify participants for more extensive testing to identify cognitive impairment. The modified mini-mental state examination (3MS) is commonly used as this initial screen in such two-stage designs, however its properties for this role require further study. PURPOSE: We use data from the Women's Health Initiative Memory Study to contrast design options in two-stage designs. METHODS: This trial enrolled 7251 participants with nine or more years of education who were aged 65-79 and followed an average of four to five years. Logistic regression was used to examine the case yields at varying two-stage 3MS cutpoints. The efficiency of using different examination schedules and restricting enrollment to higher risk women was examined. RESULTS: Probable dementia is associated with marked decline in 3MS scores. The percentages of women classified with probable dementia ranged from 7.95% (3MS 85-88) to 50.0% (3MS < 70). The numbers [95% confidence interval] of enrolled women necessary to detect one case of probable dementia (four-year follow-up) for baseline 3MS scores of 100, 95, 90 and 85 were estimated as 1477 [389, 5618], 253 [134, 481], 53 [34, 85], and 14 [9, 23], respectively. Compared to annual testing, administration every two years increased the number of required enrollees by 11%, but decreased the number of test administrations by 46%. LIMITATIONS: Our findings are influenced by the characteristics of our study group, its rates of retention, and the study protocol, and may not fully generalize to other settings. CONCLUSIONS: The 3MS can serve as an efficient basis for two-stage study designs and a cutpoint of < or = 88 is reasonable for populations with similar characteristics. Studies may improve efficiency by using the 3MS during screening to eliminate women with low risk for dementia and by conducting testing every two years.
Authors: Gregory J Tranah; Terri Blackwell; Katie L Stone; Sonia Ancoli-Israel; Misti L Paudel; Kristine E Ensrud; Jane A Cauley; Susan Redline; Teresa A Hillier; Steven R Cummings; Kristine Yaffe Journal: Ann Neurol Date: 2011-11 Impact factor: 10.422
Authors: Mark A Espeland; Stephen R Rapp; Jeff A Katula; Lee Ann Andrews; Deborah Felton; Sarah A Gaussoin; Dale Dagenbach; Claudine Legault; Janine M Jennings; Kaycee M Sink Journal: Int J Geriatr Psychiatry Date: 2011-02 Impact factor: 3.485
Authors: Caterina Rosano; Subashan Perera; Marco Inzitari; Anne B Newman; William T Longstreth; Stephanie Studenski Journal: Age Ageing Date: 2016-07-04 Impact factor: 10.668
Authors: Michael E Ward; Jeffrey M Gelfand; Li-Yung Lui; Yvonne Ou; Ari J Green; Katie Stone; Kathryn L Pedula; Steven R Cummings; Kristine Yaffe Journal: Ann Neurol Date: 2018-04-11 Impact factor: 10.422
Authors: Eileen Rillamas-Sun; Andrea Z LaCroix; Christina L Bell; Kelli Ryckman; Judith K Ockene; Robert B Wallace Journal: J Gerontol A Biol Sci Med Sci Date: 2016-03 Impact factor: 6.053
Authors: Kristine Yaffe; Laura E Middleton; Li-Yung Lui; Adam P Spira; Katie Stone; Caroline Racine; Kristine E Ensrud; Joel H Kramer Journal: Arch Neurol Date: 2011-05
Authors: Kristen E Gray; Jodie G Katon; Eileen Rillamas-Sun; Lori A Bastian; Karin M Nelson; Andrea Z LaCroix; Gayle E Reiber Journal: Gerontologist Date: 2016-02