Literature DB >> 16773703

Calcium signaling in cholangiocytes.

Noritaka Minagawa1, Barbara-E Ehrlich, Michael-H Nathanson.   

Abstract

Cytosolic Ca2+ is an important second messenger in virtually every type of cell. Moreover, Ca2+ generally regulates multiple activities within individual cells. This article reviews the cellular machinery that is responsible for Ca2+ signaling in cholangiocytes. In addition, two Ca2+-mediated events in cholangiocytes are discussed: bicarbonate secretion and apoptosis. Finally, emerging evidence is reviewed that Ca2+ signaling is involved in the pathogenesis of diseases affecting the biliary tree and that Ca2+ signaling pathways can be manipulated to therapeutic advantage in the treatment of cholestatic disorders.

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Year:  2006        PMID： 16773703      PMCID： PMC4087562          DOI： 10.3748/wjg.v12.i22.3466

Source DB:  PubMed          Journal:  World J Gastroenterol        ISSN： 1007-9327            Impact factor:   5.742


  45 in total

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  6 in total

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  6 in total

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