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Literature DB >> 16773686

Platelet-activating factor in liver injury: a relational scope.

Nikolaos-P Karidis¹, Gregory Kouraklis, Stamatios-E Theocharis.

Abstract

The hepatocyte, the main cellular component of the liver, exhibits variable susceptibility to different types of injury induced by endogenous or exogenous factors. Hepatocellular dysfunction or death and regeneration are dependent upon the complicated interactions between numerous biologically active molecules. Platelet-activating factor (PAF) seems to play a pivotal role as the key mediator of liver injury in the clinical and experimental setting, as implied by the beneficial effects of its receptor antagonists. A comprehensive up-to-date overview of the specific functional and regulatory properties of PAF in conditions associated with liver injury is attempted in this review.

Entities: Disease Gene

Mesh：

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Year: 2006 PMID： 16773686 PMCID： PMC4087462 DOI： 10.3748/wjg.v12.i23.3695

Source DB: PubMed Journal: World J Gastroenterol ISSN： 1007-9327 Impact factor: 5.742

82 in total

1. Protective effects of a PAF antagonist against liver injury induced by warm ischemia or cold preservation.

Authors: K S Wang; M Monden; T Kanai; K Umeshita; T Ukei; H Nakano; M Gotoh; T Mori
Journal: Transplant Proc Date: 1992-08 Impact factor: 1.066

2. Population of hepatic macrophages and response of perfused liver to platelet-activating factor during production of thioacetamide-induced cirrhosis in rats.

Authors: S Noda; S Masumi; M Moriyama; Y Kannan; M Ohta; T Sugano; J Yamate
Journal: Hepatology Date: 1996-08 Impact factor: 17.425

Review 3. Preservation and reperfusion injuries in liver allografts. An overview and synthesis of current studies.

Authors: P A Clavien; P R Harvey; S M Strasberg
Journal: Transplantation Date: 1992-05 Impact factor: 4.939

Review 4. Experimental models of hepatic fibrosis: a review.

Authors: H Tsukamoto; M Matsuoka; S W French
Journal: Semin Liver Dis Date: 1990-02 Impact factor: 6.115

5. Suppression of lipopolysaccharide-induced nitric oxide synthase expression by platelet-activating factor receptor antagonists in the rat liver and cultured rat Kupffer cells.

Authors: S B Mustafa; B D Flickinger; M S Olson
Journal: Hepatology Date: 1999-11 Impact factor: 17.425

6. Platelet-activating factor antagonist BN52021 improves survival in normothermic liver ischemia in rats.

Authors: F G Borobia; J Figueras; J M Escriba; L Farran; A Rafecas; J Fabregat; J Torras; E Jaurrieta
Journal: Transplant Proc Date: 1993-08 Impact factor: 1.066

7. Determinants of plasma platelet-activating factor acetylhydrolase: heritability and relationship to plasma lipoproteins.

Authors: R Guerra; B Zhao; V Mooser; D Stafforini; J M Johnston; J C Cohen
Journal: J Lipid Res Date: 1997-11 Impact factor: 5.922

8. Neutrophil infiltration as an important factor in liver ischemia and reperfusion injury. Modulating effects of FK506 and cyclosporine.

Authors: S Suzuki; L H Toledo-Pereyra; F J Rodriguez; D Cejalvo
Journal: Transplantation Date: 1993-06 Impact factor: 4.939

9. Effects of platelet-activating factor antagonist E5880 on intrahepatic and systemic metabolic responses to transient hepatic inflow occlusion and reperfusion in the rabbit.

Authors: T Nakatani; Y Sakamoto; H Ando; K Kobayashi
Journal: World J Surg Date: 1996-10 Impact factor: 3.352

Platelet-activating factor in liver injury: a relational scope.

1. Protective effects of a PAF antagonist against liver injury induced by warm ischemia or cold preservation.

2. Population of hepatic macrophages and response of perfused liver to platelet-activating factor during production of thioacetamide-induced cirrhosis in rats.

Review 3. Preservation and reperfusion injuries in liver allografts. An overview and synthesis of current studies.

Review 4. Experimental models of hepatic fibrosis: a review.

5. Suppression of lipopolysaccharide-induced nitric oxide synthase expression by platelet-activating factor receptor antagonists in the rat liver and cultured rat Kupffer cells.

6. Platelet-activating factor antagonist BN52021 improves survival in normothermic liver ischemia in rats.

7. Determinants of plasma platelet-activating factor acetylhydrolase: heritability and relationship to plasma lipoproteins.

8. Neutrophil infiltration as an important factor in liver ischemia and reperfusion injury. Modulating effects of FK506 and cyclosporine.

9. Effects of platelet-activating factor antagonist E5880 on intrahepatic and systemic metabolic responses to transient hepatic inflow occlusion and reperfusion in the rabbit.

10. Involvement of platelet activating factor in microcirculatory disturbances after global hepatic ischemia.

Review 1. Macrophages and tissue injury: agents of defense or destruction?

2. Platelet-activating factor involvement in thioacetamide-induced experimental liver fibrosis and cirrhosis.

Review 3. Silymarin/Silybin and Chronic Liver Disease: A Marriage of Many Years.

4. Clinical application of elevated platelet-activating factor acetylhydrolase in patients with hepatitis B.

Review 5. Inflammation, not Cholesterol, Is a Cause of Chronic Disease.