Literature DB >> 16773542

Two new cytotoxic naphthoquinones from Mendoncia cowanii from the rainforest of Madagascar.

Russell B Williams1, Andrew Norris, James S Miller, L Jeremie Razafitsalama, Rabodo Andriantsiferana, Vincent E Rasamison, David G Kingston.   

Abstract

Bioassay-guided fractionation of the root and stem extracts of Mendoncia cowanii led to the isolation of two new and two known naphthoquinones. The structures of the new compounds, avicequinones D and E (1 and 2), were determined using 1D and 2D NMR spectroscopy and by chemical conversion of compound 1 to 2. The new compounds were active in the A2780 human ovarian cancer cell line with IC50 values of 7.4 - 50 microM, respectively, and 1, 3, and 4 were subsequently found to be weakly active in an assay for inhibition of the kinase Akt.

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Year:  2006        PMID： 16773542      PMCID： PMC2911133          DOI： 10.1055/s-2006-931554

Source DB:  PubMed          Journal:  Planta Med        ISSN： 0032-0943            Impact factor:   3.352


  8 in total

Review 1.  Cellular survival: a play in three Akts.

Authors:  S R Datta; A Brunet; M E Greenberg
Journal:  Genes Dev       Date:  1999-11-15       Impact factor: 11.361

2.  Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor.

Authors:  A Brunet; A Bonni; M J Zigmond; M Z Lin; P Juo; L S Hu; M J Anderson; K C Arden; J Blenis; M E Greenberg
Journal:  Cell       Date:  1999-03-19       Impact factor: 41.582

3.  Cytotoxic sesquiterpene lactones from Vernonia pachyclada from the Madagascar rainforest.

Authors:  Russell B Williams; Andrew Norris; Carla Slebodnick; Joseph Merola; James S Miller; Rabodo Andriantsiferana; Vincent E Rasamison; David G I Kingston
Journal:  J Nat Prod       Date:  2005-09       Impact factor: 4.050

4.  Chemical constituents of Avicennia alba. Isolation and structural elucidation of new naphthoquinones and their analogues.

Authors:  C Ito; S Katsuno; Y Kondo; H T Tan; H Furukawa
Journal:  Chem Pharm Bull (Tokyo)       Date:  2000-03       Impact factor: 1.645

5.  DNA repair pathway stimulated by the forkhead transcription factor FOXO3a through the Gadd45 protein.

Authors:  Hien Tran; Anne Brunet; Jill M Grenier; Sandeep R Datta; Albert J Fornace; Peter S DiStefano; Lillian W Chiang; Michael E Greenberg
Journal:  Science       Date:  2002-04-19       Impact factor: 47.728

6.  Radiation survival parameters of antineoplastic drug-sensitive and -resistant human ovarian cancer cell lines and their modification by buthionine sulfoximine.

Authors:  K G Louie; B C Behrens; T J Kinsella; T C Hamilton; K R Grotzinger; W M McKoy; M A Winker; R F Ozols
Journal:  Cancer Res       Date:  1985-05       Impact factor: 12.701

7.  Regulation of cell death protease caspase-9 by phosphorylation.

Authors:  M H Cardone; N Roy; H R Stennicke; G S Salvesen; T F Franke; E Stanbridge; S Frisch; J C Reed
Journal:  Science       Date:  1998-11-13       Impact factor: 47.728

8.  Akt regulates cell survival and apoptosis at a postmitochondrial level.

Authors:  H Zhou; X M Li; J Meinkoth; R N Pittman
Journal:  J Cell Biol       Date:  2000-10-30       Impact factor: 10.539
  8 in total
  2 in total

1.  Cytotoxic clerodane diterpenoids and their hydrolysis products from Casearia nigrescens from the rainforest of Madagascar.

Authors:  Russell B Williams; Andrew Norris; James S Miller; Chris Birkinshaw; Fidy Ratovoson; Rabodo Andriantsiferana; Vincent E Rasamison; David G I Kingston
Journal:  J Nat Prod       Date:  2007-02       Impact factor: 4.050

Review 2.  Hyperhomocysteinemia, Suppressed Immunity, and Altered Oxidative Metabolism Caused by Pathogenic Microbes in Atherosclerosis and Dementia.

Authors:  Kilmer S McCully
Journal:  Front Aging Neurosci       Date:  2017-10-06       Impact factor: 5.750
  2 in total

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