| Literature DB >> 16772231 |
J P M Carmo1, L A Dias-Melicio, S A Calvi, M T S Peraçoli, A M V C Soares.
Abstract
Human monocytes activated by recombinant tumor necrosis factor alpha (TNF-alpha) exhibited significant fungicidal activity on the yeast cells of a highly virulent strain of Paracoccidioides brasiliensis. This process was significantly inhibited in the presence of catalase (CAT - a scavenger of H2O2), but not in the presence of superoxide-dismutase (SOD - a scavenger of superoxide anion) or NG-monomethyl-L-arginine (NG-MMLA - a nitric oxide inhibitor). Furthermore, there was a direct association between the intracellular killing of the fungus and the production of H2O2 by activated cells. These results strongly suggest a role for H2O2 in the killing of highly virulent strains of P. brasiliensis by TNF-alpha-activated human monocytes.Entities:
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Year: 2006 PMID： 16772231 DOI： 10.1080/13693780500536885
Source DB: PubMed Journal: Med Mycol ISSN： 1369-3786 Impact factor: 4.076