| Literature DB >> 16772000 |
Katherine Semrau1, Louise Kuhn, Prisca Kasonde, Moses Sinkala, Chipepo Kankasa, Erin Shutes, Cheswa Vwalika, Mrinal Ghosh, Grace Aldrovandi, Donald M Thea.
Abstract
The anti-malarial agent chloroquine has activity against HIV. We compared the effect of chloroquine (n = 18) to an anti-malarial agent without known anti-HIV-activity, sulfadoxine-pyrimethamine (n = 12), on breast milk HIV RNA levels among HIV-infected breastfeeding women in Zambia. After adjusting for CD4 count and plasma viral load, chloroquine was associated with a trend towards lower levels of HIV RNA in breast milk compared with sulfadoxine-pyrimethamine (P = 0.05). Higher breastmilk viral load was also observed among women receiving presumptive treatment for symptomatic malaria compared with asymptomatic controls and among controls reporting fever in the prior week. Further research is needed to determine the potential role of chloroquine in prevention of HIV transmission through breastfeeding.Entities:
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Year: 2006 PMID： 16772000 PMCID： PMC1765922 DOI： 10.1111/j.1365-3156.2006.01645.x
Source DB: PubMed Journal: Trop Med Int Health ISSN： 1360-2276 Impact factor: 2.622