OBJECTIVE: To describe long-term quality of life, intensive care, and hospital mortality in patients with acute renal and respiratory failure treated with one of two methods of renal replacement therapy (RRT). DESIGN: Cross-sectional survey of long-term survivors from a prospective observational study of two methods of RRT. SETTING: A combined surgical and medical intensive care unit in a university hospital. PATIENTS AND PARTICIPANTS: One hundred and twenty-six patients with acute renal and respiratory failure who required treatment with RRT and mechanical ventilation. Interventions. (1) RRT for acute renal failure was with either continuous hemodialysis with ultrafiltration using biocompatible membranes and prostacyclin and heparin anticoagulation (CHDF) or intermittent hemodialysis using cuprophane membranes and heparin anticoagulation (IHD); (2) Health-related quality of life in long-term survivors was assessed with the SF-36 (HRQL) questionnaire. MEASUREMENTS AND MAIN RESULTS: (1) There was no difference in ICU mortality (73.5% [39/53] IHD vs. 71.8% [46/64] CHDF, P = NS) or hospital mortality (83% [44/53] IHD vs. 76.5% [49/64] CHDF, P = NS) between the two RRT treatment groups. By 1999, there were 16 surviving patients; (2) Twelve of these survivors completed SF-36 forms (10 CHDF vs. 2 IHD). The overall physical health summary score and scores for seven of the health domains were significantly reduced. The mental health summary score and the domain mental health score did not differ from the general population. CONCLUSIONS: (1) The method of RRT used in ICU patients with ARF had no influence on survival; (2) The long-term survivors of multi-organ failure have poor physical health.
OBJECTIVE: To describe long-term quality of life, intensive care, and hospital mortality in patients with acute renal and respiratory failure treated with one of two methods of renal replacement therapy (RRT). DESIGN: Cross-sectional survey of long-term survivors from a prospective observational study of two methods of RRT. SETTING: A combined surgical and medical intensive care unit in a university hospital. PATIENTS AND PARTICIPANTS: One hundred and twenty-six patients with acute renal and respiratory failure who required treatment with RRT and mechanical ventilation. Interventions. (1) RRT for acute renal failure was with either continuous hemodialysis with ultrafiltration using biocompatible membranes and prostacyclin and heparin anticoagulation (CHDF) or intermittent hemodialysis using cuprophane membranes and heparin anticoagulation (IHD); (2) Health-related quality of life in long-term survivors was assessed with the SF-36 (HRQL) questionnaire. MEASUREMENTS AND MAIN RESULTS: (1) There was no difference in ICU mortality (73.5% [39/53] IHD vs. 71.8% [46/64] CHDF, P = NS) or hospital mortality (83% [44/53] IHD vs. 76.5% [49/64] CHDF, P = NS) between the two RRT treatment groups. By 1999, there were 16 surviving patients; (2) Twelve of these survivors completed SF-36 forms (10 CHDF vs. 2 IHD). The overall physical health summary score and scores for seven of the health domains were significantly reduced. The mental health summary score and the domain mental health score did not differ from the general population. CONCLUSIONS: (1) The method of RRT used in ICU patients with ARF had no influence on survival; (2) The long-term survivors of multi-organ failure have poor physical health.
Authors: Pierre-Marc Villeneuve; Edward G Clark; Lindsey Sikora; Manish M Sood; Sean M Bagshaw Journal: Intensive Care Med Date: 2015-12-01 Impact factor: 17.440
Authors: Aaron S Yarlas; Michelle K White; Min Yang; Renee N Saris-Baglama; Peter Galthen Bech; Torsten Christensen Journal: Qual Life Res Date: 2010-10-23 Impact factor: 4.147
Authors: Rinaldo Bellomo; Claudio Ronco; Ravindra L Mehta; Pierre Asfar; Julie Boisramé-Helms; Michael Darmon; Jean-Luc Diehl; Jacques Duranteau; Eric A J Hoste; Joannes-Boyau Olivier; Matthieu Legrand; Nicolas Lerolle; Manu L N G Malbrain; Johan Mårtensson; Heleen M Oudemans-van Straaten; Jean-Jacques Parienti; Didier Payen; Sophie Perinel; Esther Peters; Peter Pickkers; Eric Rondeau; Miet Schetz; Christophe Vinsonneau; Julia Wendon; Ling Zhang; Pierre-François Laterre Journal: Ann Intensive Care Date: 2017-05-04 Impact factor: 6.925
Authors: B Delannoy; B Floccard; F Thiolliere; M Kaaki; M Badet; S Rosselli; C E Ber; A Saez; G Flandreau; Claude Guérin Journal: Intensive Care Med Date: 2009-08-20 Impact factor: 17.440