Anthony Atala1. 1. Department of Urology, Wake Forest University School of Medicine, Institute for Regenerative Medicine, Winston Salem, North Carolina 27157, USA. aatala@wfubmc.edu
Abstract
PURPOSE OF REVIEW: A severe shortage of donor tissues and organs exists, which is worsening yearly given the aging population. Currently, patients suffering from diseased and injured organs are treated with transplanted organs or cells. This paper reviews recent advances that have occurred in regenerative medicine and describes application of new technologies to treat diseased or damaged organs and tissues. RECENT FINDINGS: Although most current strategies for tissue engineering depend upon a sample of autologous cells from the diseased organ of the patient, biopsies from patients with extensive end-stage organ failure may not yield enough normal cells. In these situations, stem cells are envisioned as being an alternative source. Stem cells can be derived from discarded human embryos (human embryonic stem cells), from fetal tissue, or from adult sources (bone marrow, fat, skin). Therapeutic cloning offers a potentially limitless source of cells for tissue engineering applications. SUMMARY: Recently, scientists in the fields of regenerative medicine and tissue engineering have applied the principles of cell transplantation, material science, and bioengineering to construct biological substitutes that will restore and maintain normal function in diseased and injured tissues.
PURPOSE OF REVIEW: A severe shortage of donor tissues and organs exists, which is worsening yearly given the aging population. Currently, patients suffering from diseased and injured organs are treated with transplanted organs or cells. This paper reviews recent advances that have occurred in regenerative medicine and describes application of new technologies to treat diseased or damaged organs and tissues. RECENT FINDINGS: Although most current strategies for tissue engineering depend upon a sample of autologous cells from the diseased organ of the patient, biopsies from patients with extensive end-stage organ failure may not yield enough normal cells. In these situations, stem cells are envisioned as being an alternative source. Stem cells can be derived from discarded human embryos (human embryonic stem cells), from fetal tissue, or from adult sources (bone marrow, fat, skin). Therapeutic cloning offers a potentially limitless source of cells for tissue engineering applications. SUMMARY: Recently, scientists in the fields of regenerative medicine and tissue engineering have applied the principles of cell transplantation, material science, and bioengineering to construct biological substitutes that will restore and maintain normal function in diseased and injured tissues.
Authors: Edward A Ross; Matthew J Williams; Takashi Hamazaki; Naohiro Terada; William L Clapp; Christopher Adin; Gary W Ellison; Marda Jorgensen; Christopher D Batich Journal: J Am Soc Nephrol Date: 2009-09-03 Impact factor: 10.121
Authors: Edward A Ross; Dale R Abrahamson; Patricia St John; William L Clapp; Matthew J Williams; Naohiro Terada; Takashi Hamazaki; Gary W Ellison; Christopher D Batich Journal: Organogenesis Date: 2012-04-01 Impact factor: 2.500