Literature DB >> 16769591

The association between multidrug resistance-1 gene polymorphisms and outcomes of allogeneic HLA-identical stem cell transplantation.

Dong Hwan Kim1, Jae Yong Park, Sang Kyun Sohn, Nan Young Lee, Jang Soo Suh, Kyu Bo Lee.   

Abstract

The impact of single nucleotide polymorphisms of two loci (C3435T and G2677T/A) of the multidrug resistance-1 gene (MDR1) was investigated in 82 patients undergoing allogeneic stem cell transplantation (SCT). The GG genotype on G2677T/A loci was associated with higher non-relapse mortality than was the non-GG genotype (67% vs. 32%, p=0.0073), but not the C3435T (p=0.2026) or MDR1 haplotype (p=0.2238). Accordingly, overall survival was significantly correlated with the G2677T/A genotype (p=0.0048). Multivariate analysis also showed that the GG genotype at G2677T/A had an unfavorable prognosis in terms of overall survival (p=0.003) and non-relapse mortality (p=0.031). In conclusion, the G2677T/A genotype seems to be associated with transplantation outcomes, especially non-relapse mortality.

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Year:  2006        PMID： 16769591

Source DB:  PubMed          Journal:  Haematologica        ISSN： 0390-6078            Impact factor:   9.941


  5 in total

1.  Replication and validation of genetic polymorphisms associated with survival after allogeneic blood or marrow transplant.

Authors:  Ezgi Karaesmen; Abbas A Rizvi; Leah M Preus; Philip L McCarthy; Marcelo C Pasquini; Kenan Onel; Xiaochun Zhu; Stephen Spellman; Christopher A Haiman; Daniel O Stram; Loreall Pooler; Xin Sheng; Qianqian Zhu; Li Yan; Qian Liu; Qiang Hu; Amy Webb; Guy Brock; Alyssa I Clay-Gilmour; Sebastiano Battaglia; David Tritchler; Song Liu; Theresa Hahn; Lara E Sucheston-Campbell
Journal:  Blood       Date:  2017-08-15       Impact factor: 22.113

2.  MDR-1 polymorphisms (G2677T and C3435T) in B-chronic lymphocytic leukemia: an impact on susceptibility and prognosis.

Authors:  G Penna; A Allegra; A Alonci; M Aguennouz; A Garufi; A Cannavò; D Gerace; A Alibrandi; C Musolino
Journal:  Med Oncol       Date:  2010-05-22       Impact factor: 3.064

3.  Race and socioeconomic status influence outcomes of unrelated donor hematopoietic cell transplantation.

Authors:  K Scott Baker; Stella M Davies; Navneet S Majhail; Anna Hassebroek; John P Klein; Karen K Ballen; Carolyn L Bigelow; Haydar A Frangoul; Cheryl L Hardy; Christopher Bredeson; Jason Dehn; Debra Friedman; Theresa Hahn; Gregory Hale; Hillard M Lazarus; C F LeMaistre; Fausto Loberiza; Dipnarine Maharaj; Philip McCarthy; Michelle Setterholm; Stephen Spellman; Michael Trigg; Richard T Maziarz; Galen Switzer; Stephanie J Lee; J Douglas Rizzo
Journal:  Biol Blood Marrow Transplant       Date:  2009-09-25       Impact factor: 5.742

4.  Predicting survival using clinical risk scores and non-HLA immunogenetics.

Authors:  Y Balavarca; K Pearce; J Norden; M Collin; G Jackson; E Holler; R Dressel; H-J Kolb; H Greinix; G Socie; A Toubert; V Rocha; E Gluckman; I Hromadnikova; P Sedlacek; D Wolff; U Holtick; A Dickinson; H Bickeböller
Journal:  Bone Marrow Transplant       Date:  2015-07-27       Impact factor: 5.483

Review 5.  Clarifying busulfan metabolism and drug interactions to support new therapeutic drug monitoring strategies: a comprehensive review.

Authors:  Alan L Myers; Jitesh D Kawedia; Richard E Champlin; Mark A Kramer; Yago Nieto; Romi Ghose; Borje S Andersson
Journal:  Expert Opin Drug Metab Toxicol       Date:  2017-08-17       Impact factor: 4.481
  5 in total

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