Literature DB >> 1676880

Aberrant cytoplasmic expression of proliferating cell nuclear antigen in Hodgkin's disease.

D R Benjamin1, A M Gown.   

Abstract

During a study using a monoclonal antibody directed against proliferating cell nuclear antigen (PCNA) to assess the proliferative activity of tumors, it was noted that the cytoplasm of Reed-Sternberg (RS) cells and variants of these cells in cases of Hodgkin's disease reacted very positively. This aberrant expression of PCNA has not been observed in any other tumor or in cells from normal tissues. The biological significance of this observation is currently unknown, but it may have diagnostic utility in detecting and identifying RS cells.

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Year:  1991        PMID： 1676880     DOI： 10.1097/00000478-199108000-00006

Source DB:  PubMed          Journal:  Am J Surg Pathol        ISSN： 0147-5185            Impact factor:   6.394


  7 in total

1.  Immunohistochemical location of prothymosin alpha in regenerating human hepatocytes and hepatocellular carcinomas.

Authors:  M Fraga; T García-Caballero; F Domínguez; E Pérez-Becerra; A Beiras; J Forteza
Journal:  Virchows Arch A Pathol Anat Histopathol       Date:  1993

2.  PC10 monoclonal antibody to proliferating cell nuclear antigen as probe for cycling cell detection in developing tissues. A combined immunocytochemical and flow cytometric study.

Authors:  A Casasco; M Giordano; M Danova; M Casasco; A Icaro Cornaglia; A Calligaro
Journal:  Histochemistry       Date:  1993-03

3.  Inhibitory effect of Kangjia Pill on thyrocyte proliferation in rat goiter model.

Authors:  Yong Han; Jing Zhou; Shu-jing Yu; Bin Cui; Hai-qing Zhang; Ling Gao; Jia-jun Zhao
Journal:  Chin J Integr Med       Date:  2009-08-18       Impact factor: 1.978

4.  Immunostaining for proliferating cell nuclear antigen: its role in determination of proliferation in routinely processed human brain tumor specimens.

Authors:  S Khoshyomn; H Maier; T Morimura; K Kitz; H Budka
Journal:  Acta Neuropathol       Date:  1993       Impact factor: 17.088

5.  Proliferating cell nuclear antigen (PCNA) expression in regenerating rat liver after partial hepatectomy.

Authors:  S E Theocharis; A S Skopelitou; A P Margeli; K J Pavlaki; C Kittas
Journal:  Dig Dis Sci       Date:  1994-02       Impact factor: 3.199

6.  Proliferating cell nuclear antigen (PCNA) and nucleolar organiser regions in Hodgkin's disease: correlation with morphology.

Authors:  J Freeman; D B Kellock; C C Yu; J Crocker; D A Levison; P A Hall
Journal:  J Clin Pathol       Date:  1993-05       Impact factor: 3.411

7.  Cell proliferation of transitional cell bladder tumours determined by PCNA/cyclin immunostaining and its prognostic value.

Authors:  P K Lipponen; M J Eskelinen
Journal:  Br J Cancer       Date:  1992-07       Impact factor: 7.640
  7 in total

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