Literature DB >> 16768517

pH-induced release from P2VP-PEO block copolymer vesicles.

Uwe Borchert1, Ute Lipprandt, Matthias Bilang, Andrea Kimpfler, Anja Rank, Regine Peschka-Süss, Rolf Schubert, Peter Lindner, Stephan Förster.   

Abstract

The pH-induced release of hydrophilic dyes from poly(2-vinylpyridine-b-ethylene oxide) (P2VP-PEO) block copolymer vesicles is investigated. The structure of the vesicles is characterized using small-angle neutron scattering (SANS) and cryo-electron microscopy (cryo-TEM). A decrease of the pH below 5 leads to protonation and dissolution of the poly-2-vinylpyridine blocks which induces rupture and dissolution of the vesicle membrane. Details of the rupture, dissolution, and release process are studied by fluorescence video microscopy, gel electrophoresis, and high-performance ultrafiltration.

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Year:  2006        PMID： 16768517     DOI： 10.1021/la060227t

Source DB:  PubMed          Journal:  Langmuir        ISSN： 0743-7463            Impact factor:   3.882


  16 in total

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