BACKGROUND: An association between diesel exhaust exposure and lung cancer mortality in a large retrospective cohort study of US railroad workers has previously been reported. However, specific information regarding cigarette smoking was unavailable. METHODS: Birth cohort, age, job, and cause of death specific smoking histories from a companion case-control study were used to impute smoking behavior for 39,388 railroad workers who died 1959-1996. Mortality analyses incorporated the effect of smoking on lung cancer risk. RESULTS: The smoking adjusted relative risk of lung cancer in railroad workers exposed to diesel exhaust compared to unexposed workers was 1.22 (95% CI = 1.12-1.32), and unadjusted for smoking the relative risk was 1.35 (95% CI = 1.24-1.46). CONCLUSIONS: These analyses illustrate the use of imputation in record-based occupational health studies to assess potential confounding due to smoking. In this cohort, small differences in smoking behavior between diesel exposed and unexposed workers did not explain the elevated lung cancer risk.
BACKGROUND: An association between diesel exhaust exposure and lung cancer mortality in a large retrospective cohort study of US railroad workers has previously been reported. However, specific information regarding cigarette smoking was unavailable. METHODS: Birth cohort, age, job, and cause of death specific smoking histories from a companion case-control study were used to impute smoking behavior for 39,388 railroad workers who died 1959-1996. Mortality analyses incorporated the effect of smoking on lung cancer risk. RESULTS: The smoking adjusted relative risk of lung cancer in railroad workers exposed to diesel exhaust compared to unexposed workers was 1.22 (95% CI = 1.12-1.32), and unadjusted for smoking the relative risk was 1.35 (95% CI = 1.24-1.46). CONCLUSIONS: These analyses illustrate the use of imputation in record-based occupational health studies to assess potential confounding due to smoking. In this cohort, small differences in smoking behavior between diesel exposed and unexposed workers did not explain the elevated lung cancer risk.
Authors: Eric Garshick; Francine Laden; Jaime E Hart; Bernard Rosner; Thomas J Smith; Douglas W Dockery; Frank E Speizer Journal: Environ Health Perspect Date: 2004-11 Impact factor: 9.031
Authors: Thomas W Hesterberg; Christopher M Long; William B Bunn; Charles A Lapin; Roger O McClellan; Peter A Valberg Journal: Inhal Toxicol Date: 2012-06-04 Impact factor: 2.724
Authors: Jaime E Hart; Eric Garshick; Douglas W Dockery; Thomas J Smith; Louise Ryan; Francine Laden Journal: Am J Respir Crit Care Med Date: 2010-07-23 Impact factor: 21.405
Authors: Rebecca J Sheesley; James J Schauer; Eric Garshick; Francine Laden; Thomas J Smith; Andrew P Blicharz; Jeffrey T Deminter Journal: J Expo Sci Environ Epidemiol Date: 2008-03-05 Impact factor: 5.563
Authors: Hongwei Tang; Peng Wei; Eric J Duell; Harvey A Risch; Sara H Olson; H Bas Bueno-de-Mesquita; Steven Gallinger; Elizabeth A Holly; Gloria Petersen; Paige M Bracci; Robert R McWilliams; Mazda Jenab; Elio Riboli; Anne Tjønneland; Marie Christine Boutron-Ruault; Rudolph Kaaks; Dimitrios Trichopoulos; Salvatore Panico; Malin Sund; Petra H M Peeters; Kay-Tee Khaw; Christopher I Amos; Donghui Li Journal: Carcinogenesis Date: 2014-01-13 Impact factor: 4.741
Authors: Thomas P McKeon; Wei-Ting Hwang; Zhuoran Ding; Vicky Tam; Paul Wileyto; Karen Glanz; Trevor M Penning Journal: Environ Sci Pollut Res Int Date: 2021-02-21 Impact factor: 4.223