Literature DB >> 16767478

[Targeted therapy in the treatment of solid tumors and in hematology-oncology. Advances and disappointments].

C Jochims1, U Mazitschek, D Jäger, H Goldschmidt.   

Abstract

The development and clinical introduction of targeted therapies has resulted in significant progress for the treatment of malignant diseases. These forms of therapy supplement traditional methods of chemotherapy, radiation, and surgery. As new therapies increase the complexity of therapeutic options in oncology, the treatment costs steadily climb as well. Parameters need to be identified which will predict a response to new substances, and this effort is the subject of ongoing studies.

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Year:  2006        PMID: 16767478     DOI: 10.1007/s00108-006-1626-7

Source DB:  PubMed          Journal:  Internist (Berl)        ISSN: 0020-9554            Impact factor:   0.743


  21 in total

1.  Salvage therapy for multiple myeloma with thalidomide and CED chemotherapy.

Authors:  T M Moehler; K Neben; A Benner; G Egerer; F Krasniqi; A D Ho; H Goldschmidt
Journal:  Blood       Date:  2001-12-15       Impact factor: 22.113

2.  E2100: a phase III trial of paclitaxel versus paclitaxel/bevacizumab for metastatic breast cancer.

Authors:  Kathy D Miller
Journal:  Clin Breast Cancer       Date:  2003-02       Impact factor: 3.225

Review 3.  [Basics of molecular diagnostics and therapy of malignant tumors].

Authors:  P T Daniel; B Dörken
Journal:  Internist (Berl)       Date:  2005-08       Impact factor: 0.743

Review 4.  A systematic review of phase-II trials of thalidomide monotherapy in patients with relapsed or refractory multiple myeloma.

Authors:  Axel Glasmacher; Corinna Hahn; Florian Hoffmann; Ralph Naumann; Hartmut Goldschmidt; Marie von Lilienfeld-Toal; Katjana Orlopp; Ingo Schmidt-Wolf; Marcus Gorschlüter
Journal:  Br J Haematol       Date:  2006-03       Impact factor: 6.998

5.  Treatment of metastatic renal cell carcinoma with a combination of bevacizumab and erlotinib.

Authors:  John D Hainsworth; Jeffrey A Sosman; David R Spigel; Donna L Edwards; Cara Baughman; Anthony Greco
Journal:  J Clin Oncol       Date:  2005-10-03       Impact factor: 44.544

6.  Erlotinib in lung cancer - molecular and clinical predictors of outcome.

Authors:  Ming-Sound Tsao; Akira Sakurada; Jean-Claude Cutz; Chang-Qi Zhu; Suzanne Kamel-Reid; Jeremy Squire; Ian Lorimer; Tong Zhang; Ni Liu; Manijeh Daneshmand; Paula Marrano; Gilda da Cunha Santos; Alain Lagarde; Frank Richardson; Lesley Seymour; Marlo Whitehead; Keyue Ding; Joseph Pater; Frances A Shepherd
Journal:  N Engl J Med       Date:  2005-07-14       Impact factor: 91.245

7.  Trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer.

Authors:  Martine J Piccart-Gebhart; Marion Procter; Brian Leyland-Jones; Aron Goldhirsch; Michael Untch; Ian Smith; Luca Gianni; Jose Baselga; Richard Bell; Christian Jackisch; David Cameron; Mitch Dowsett; Carlos H Barrios; Günther Steger; Chiun-Shen Huang; Michael Andersson; Moshe Inbar; Mikhail Lichinitser; István Láng; Ulrike Nitz; Hiroji Iwata; Christoph Thomssen; Caroline Lohrisch; Thomas M Suter; Josef Rüschoff; Tamás Suto; Victoria Greatorex; Carol Ward; Carolyn Straehle; Eleanor McFadden; M Stella Dolci; Richard D Gelber
Journal:  N Engl J Med       Date:  2005-10-20       Impact factor: 91.245

8.  EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib.

Authors:  William Pao; Vincent Miller; Maureen Zakowski; Jennifer Doherty; Katerina Politi; Inderpal Sarkaria; Bhuvanesh Singh; Robert Heelan; Valerie Rusch; Lucinda Fulton; Elaine Mardis; Doris Kupfer; Richard Wilson; Mark Kris; Harold Varmus
Journal:  Proc Natl Acad Sci U S A       Date:  2004-08-25       Impact factor: 11.205

9.  Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer.

Authors:  Herbert Hurwitz; Louis Fehrenbacher; William Novotny; Thomas Cartwright; John Hainsworth; William Heim; Jordan Berlin; Ari Baron; Susan Griffing; Eric Holmgren; Napoleone Ferrara; Gwen Fyfe; Beth Rogers; Robert Ross; Fairooz Kabbinavar
Journal:  N Engl J Med       Date:  2004-06-03       Impact factor: 91.245

10.  Imatinib and beyond--the new CML study IV. A randomized controlled comparison of imatinib vs imatinib/interferon-alpha vs imatinib/low-dose AraC vs imatinib after interferon-alpha failure in newly diagnosed chronic phase chronic myeloid leukemia.

Authors:  U Berger; G Engelich; A Reiter; A Hochhaus; R Hehlmann
Journal:  Ann Hematol       Date:  2003-11-29       Impact factor: 3.673

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