Literature DB >> 16767477

[A 67-year-old patient with somnolence and severe hyponatraemia].

J Seiderer1, C Rust, M Menth, T Pusl, M Jung.   

Abstract

A 67-year-old female patient with known depression was admitted to the intensive care unit with severe hyponatraemia (105 mmol/l) and somnolence caused by inadequate antidiuretic hormone secretion (SIADH) syndrome after starting therapy with the selective serotonin reuptake inhibitor (SSRI) Citalopram. This medication was stopped, and the hyponatraemia was carefully treated with fluid restriction and diuretics. Seven days later, the patient was discharged to a psychiatric ward with normal sodium levels and markedly improved vigilance. Given the increased use of SSRI for medical treatment of depression, the risk factors of this rare but potentially life-threatening complication and the diagnostic and therapeutic options are discussed.

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Year:  2006        PMID: 16767477     DOI: 10.1007/s00108-006-1612-0

Source DB:  PubMed          Journal:  Internist (Berl)        ISSN: 0020-9554            Impact factor:   0.743


  10 in total

Review 1.  Hyponatremia.

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Journal:  N Engl J Med       Date:  2000-05-25       Impact factor: 91.245

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Review 3.  Central pontine and extrapontine myelinolysis: the osmotic demyelination syndromes.

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Authors:  Claire-Marie Vacher; Philippe Frétier; Christophe Créminon; André Calas; Hélène Hardin-Pouzet
Journal:  J Neurosci       Date:  2002-03-01       Impact factor: 6.167

5.  Incidence and risk factors for hyponatraemia following treatment with fluoxetine or paroxetine in elderly people.

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Journal:  Br J Clin Pharmacol       Date:  1999-02       Impact factor: 4.335

6.  Serotonin receptors involved in vasopressin and oxytocin secretion.

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7.  Citalopram-associated SIADH.

Authors:  Teresa S Barclay; Audrey J Lee
Journal:  Ann Pharmacother       Date:  2002-10       Impact factor: 3.154

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Journal:  Ann Pharmacother       Date:  2003-11       Impact factor: 3.154

9.  Severe adverse drug reactions of antidepressants: results of the German multicenter drug surveillance program AMSP.

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Journal:  Pharmacopsychiatry       Date:  2004-03       Impact factor: 5.788

10.  Severe hyponatremia associated with the combined use of thiazide diuretics and selective serotonin reuptake inhibitors.

Authors:  Mitchell H Rosner
Journal:  Am J Med Sci       Date:  2004-02       Impact factor: 2.378

  10 in total
  1 in total

Review 1.  [Drug-related disorders of water and electrolyte metabolism].

Authors:  U Dendorfer; J Mann
Journal:  Internist (Berl)       Date:  2006-11       Impact factor: 0.743

  1 in total

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