Literature DB >> 16767078

A consensus epitope prediction approach identifies the breadth of murine T(CD8+)-cell responses to vaccinia virus.

Magdalini Moutaftsi1, Bjoern Peters, Valerie Pasquetto, David C Tscharke, John Sidney, Huynh-Hoa Bui, Howard Grey, Alessandro Sette.   

Abstract

The value of predictive algorithms for identifying CD8+ T (T(CD8+))-cell epitopes has not been adequately tested experimentally. Here we demonstrate that conventional bioinformatic methods predict the vast majority of T(CD8+)-cell epitopes derived from vaccinia virus WR strain (VACV-WR) in the H-2(b) mouse model. This approach reveals the breadth of T-cell responses to vaccinia, a widely studied murine viral infection model, and may provide a tool for developing comprehensive antigenic maps of any complex pathogen.

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Year:  2006        PMID： 16767078     DOI： 10.1038/nbt1215

Source DB:  PubMed          Journal:  Nat Biotechnol        ISSN： 1087-0156            Impact factor:   54.908


  256 in total

1.  Predictions versus high-throughput experiments in T-cell epitope discovery: competition or synergy?

Authors:  Claus Lundegaard; Ole Lund; Morten Nielsen
Journal:  Expert Rev Vaccines       Date:  2012-01       Impact factor: 5.217

Review 2.  Heterologous immunity between viruses.

Authors:  Raymond M Welsh; Jenny W Che; Michael A Brehm; Liisa K Selin
Journal:  Immunol Rev       Date:  2010-05       Impact factor: 12.988

3.  Immediate-early expression of a recombinant antigen by modified vaccinia virus ankara breaks the immunodominance of strong vector-specific B8R antigen in acute and memory CD8 T-cell responses.

Authors:  Karen Baur; Kay Brinkmann; Marc Schweneker; Juliane Pätzold; Christine Meisinger-Henschel; Judith Hermann; Robin Steigerwald; Paul Chaplin; Mark Suter; Jürgen Hausmann
Journal:  J Virol       Date:  2010-06-10       Impact factor: 5.103

4.  Towards an immunosense vaccine to prevent toxoplasmosis: protective Toxoplasma gondii epitopes restricted by HLA-A*0201.

Authors:  Hua Cong; Ernest J Mui; William H Witola; John Sidney; Jeff Alexander; Alessandro Sette; Ajesh Maewal; Rima McLeod
Journal:  Vaccine       Date:  2010-11-21       Impact factor: 3.641

5.  Promiscuous binding of extracellular peptides to cell surface class I MHC protein.

Authors:  Herman N Eisen; Xun Helen Hou; Chase Shen; Kaidi Wang; Varsha Keelara Tanguturi; Crysela Smith; Katerina Kozyrytska; Lakshmi Nambiar; Carol A McKinley; Jianzhu Chen; Richard J Cohen
Journal:  Proc Natl Acad Sci U S A       Date:  2012-03-07       Impact factor: 11.205

6.  NetMHCcons: a consensus method for the major histocompatibility complex class I predictions.

Authors:  Edita Karosiene; Claus Lundegaard; Ole Lund; Morten Nielsen
Journal:  Immunogenetics       Date:  2011-10-20       Impact factor: 2.846

Review 7.  Major histocompatibility complex class I binding predictions as a tool in epitope discovery.

Authors:  Claus Lundegaard; Ole Lund; Søren Buus; Morten Nielsen
Journal:  Immunology       Date:  2010-05-26       Impact factor: 7.397

8.  HLArestrictor--a tool for patient-specific predictions of HLA restriction elements and optimal epitopes within peptides.

Authors:  Malene Erup Larsen; Henrik Kloverpris; Anette Stryhn; Catherine K Koofhethile; Stuart Sims; Thumbi Ndung'u; Philip Goulder; Søren Buus; Morten Nielsen
Journal:  Immunogenetics       Date:  2010-11-16       Impact factor: 2.846

9.  Analysis of CD8+ T cell response during the 2013-2016 Ebola epidemic in West Africa.

Authors:  Saori Sakabe; Brian M Sullivan; Jessica N Hartnett; Refugio Robles-Sikisaka; Karthik Gangavarapu; Beatrice Cubitt; Brian C Ware; Dylan Kotliar; Luis M Branco; Augustine Goba; Mambu Momoh; John Demby Sandi; Lansana Kanneh; Donald S Grant; Robert F Garry; Kristian G Andersen; Juan Carlos de la Torre; Pardis C Sabeti; John S Schieffelin; Michael B A Oldstone
Journal:  Proc Natl Acad Sci U S A       Date:  2018-07-23       Impact factor: 11.205

10.  Preferential use of B7.2 and not B7.1 in priming of vaccinia virus-specific CD8 T cells.

Authors:  Shahram Salek-Ardakani; Ramon Arens; Rachel Flynn; Alessandro Sette; Stephen P Schoenberger; Michael Croft
Journal:  J Immunol       Date:  2009-03-01       Impact factor: 5.422
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