| Literature DB >> 16766184 |
Sanjay K Srivastava1, Aji Abraham, Beena Bhat, Manu Jaggi, Anu T Singh, Vinod K Sanna, Gurvinder Singh, Shiv K Agarwal, Rama Mukherjee, Anand C Burman.
Abstract
A number of costunolide derivatives (4a-p) have been synthesized and evaluated for their in vitro cytotoxicity against eight tumor and a non-tumor cell lines. Compound 4d showed around 2-fold better cytotoxicity against SW-620 (colon) cell line with improved safety index than costunolide (1). While compounds 4e, 4g, and 4p have shown around 2- to 3-fold better cytotoxicity against MIAPaCa2 (pancreas), K-562 (leukemia) and PA-1 (ovary) cell lines as well as better safety index in comparison to costunolide (1). Compound 4p also exhibited cytotoxicity against HBL100 (breast) cell line with 2-fold better safety index. Structure-activity relationship has been described.Entities:
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Year: 2006 PMID： 16766184 DOI： 10.1016/j.bmcl.2006.05.083
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823