Literature DB >> 16766183

Synthesis of biotinylated photoaffinity probes based on arylsulfonamide gamma-secretase inhibitors.

Haruhiko Fuwa1, Kenichi Hiromoto, Yasuko Takahashi, Satoshi Yokoshima, Toshiyuki Kan, Tohru Fukuyama, Takeshi Iwatsubo, Taisuke Tomita, Hideaki Natsugari.   

Abstract

Synthesis and biological evaluation of an arylsulfonamide class of gamma-secretase inhibitors are described. Design, synthesis, and biological evaluation of multifunctional molecular probes harboring a benzophenone photophore as a cross-linking group and a biotin tag are also reported.

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Year:  2006        PMID: 16766183     DOI: 10.1016/j.bmcl.2006.05.091

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN: 0960-894X            Impact factor:   2.823


  3 in total

Review 1.  At the frontline of Alzheimer's disease treatment: gamma-secretase inhibitor/modulator mechanism.

Authors:  Taisuke Tomita
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2007-11-24       Impact factor: 3.000

2.  Binding is not enough: flexibility is needed for photocrosslinking of Lck kinase by benzophenone photoligands.

Authors:  Akira Kawamura; Sagit Hindi; Doina M Mihai; Laurence James; Olga Aminova
Journal:  Bioorg Med Chem       Date:  2008-09-03       Impact factor: 3.641

3.  Chemical Biology, Molecular Mechanism and Clinical Perspective of γ-Secretase Modulators in Alzheimer's Disease.

Authors:  Bruno Bulic; Julia Ness; Stefanie Hahn; Andreas Rennhack; Thorsten Jumpertz; Sascha Weggen
Journal:  Curr Neuropharmacol       Date:  2011-12       Impact factor: 7.363

  3 in total

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