PURPOSE: To investigate the association between central nervous system (CNS) inflammation at disease onset and the appearance of sunset glow fundus (SGF) in Vogt-Koyanagi-Harada (VKH) disease. DESIGN: Retrospective case series. METHODS: Charts of 102 patients with VKH disease followed from from initial onset were reviewed. The frequency of cerebrospinal fluid (CSF) pleocytosis and the number of cells in the CSF were compared among the patients who eventually developed SGF and the patients who had not developed SGF as of final follow-up. RESULTS: SGF was observed in 69 (67.6%) of 102 patients. The frequency of CSF pleocytosis was 77 (82.7%) of 93 patients examined. The frequency of CSF pleocytosis and the number of cells in CSF were significantly higher in patients who eventually developed SGF (both P = .0029). CONCLUSIONS: Severe inflammatory response in CNS sites at disease onset may influence the development of SGF in VKH disease.
PURPOSE: To investigate the association between central nervous system (CNS) inflammation at disease onset and the appearance of sunset glow fundus (SGF) in Vogt-Koyanagi-Harada (VKH) disease. DESIGN: Retrospective case series. METHODS: Charts of 102 patients with VKH disease followed from from initial onset were reviewed. The frequency of cerebrospinal fluid (CSF) pleocytosis and the number of cells in the CSF were compared among the patients who eventually developed SGF and the patients who had not developed SGF as of final follow-up. RESULTS: SGF was observed in 69 (67.6%) of 102 patients. The frequency of CSF pleocytosis was 77 (82.7%) of 93 patients examined. The frequency of CSF pleocytosis and the number of cells in CSF were significantly higher in patients who eventually developed SGF (both P = .0029). CONCLUSIONS: Severe inflammatory response in CNS sites at disease onset may influence the development of SGF in VKH disease.
Authors: Carl P Herbort; Ahmed M Abu El Asrar; Joyce H Yamamoto; Carlos E Pavésio; Vishali Gupta; Moncef Khairallah; Ilknur Tugal-Tutkun; Masoud Soheilian; Masuru Takeuchi; Marina Papadia Journal: Int Ophthalmol Date: 2016-11-14 Impact factor: 2.031