| Literature DB >> 16765397 |
Dominique A Caugant1, Carole Fogg, Francis Bajunirwe, Patrice Piola, Rogers Twesigye, Fred Mutebi, L Oddvar Frøholm, Einar Rosenqvist, Vincent Batwala, Ingeborg S Aaberge, John-Arne Rottingen, Philippe J Guerin.
Abstract
In southern Uganda, only sporadic cases of serogroup A meningococcal disease have been reported since 2000. As part of an immunogenicity study of the tetravalent meningococcal polysaccharide vaccine, nasopharyngeal swab samples were collected twice, 4 weeks apart, from 2-19-year-old healthy individuals in Mbarara, Uganda. Only 15 (2.0%) of the 750 individuals carried meningococci asymptomatically. Most of the strains were non-serogroupable and none were serogroup A. However, two individuals carried a serogroup W135 strain, sequence type (ST)-11, similar to the clone that was responsible for the epidemic in Burkina Faso in 2002. Our study further demonstrates the geographical spread of serogroup W135 ST-11 strain and thus the potential epidemic risk.Entities:
Mesh：
Year: 2006 PMID： 16765397 DOI： 10.1016/j.trstmh.2006.01.004
Source DB: PubMed Journal: Trans R Soc Trop Med Hyg ISSN： 0035-9203 Impact factor: 2.184