Literature DB >> 16765311

Osteopontin is involved in Th1-mediated immunity against Plasmodium falciparum infection in a holoendemic malaria region in Vietnam.

Yoshimasa Maeno1, Shusuke Nakazawa, Le Duc Dao, Nguyen Van Tuan, Nguyen Duc Giang, Truong Van Hanh, Koki Taniguchi.   

Abstract

We examined the role of osteopontin (OPN) in immunity against Plasmodium falciparum infection. We measured the mRNA levels for OPN and several cytokines in RNA preparations extracted from dried blood on filter paper obtained from falciparum malaria patients in Vietnam. Expression of OPN mRNA was detected in 134 of 161 patients. The expression of both interleukin-12 p40 and interferon-gamma mRNAs in the group positive for OPN mRNA was significantly higher than that in the group negative for OPN mRNA. The level of parasitemia in the OPN mRNA-positive group was much lower than that in the negative one. These results suggest that OPN might suppress multiplication of the parasites through T helper 1 cells-mediated immune responses.

Entities:  

Mesh：

Substances：

Year:  2006        PMID： 16765311     DOI： 10.1016/j.actatropica.2006.05.001

Source DB:  PubMed          Journal:  Acta Trop        ISSN： 0001-706X            Impact factor:   3.112


  4 in total

1.  Severity predictors in eschar-positive scrub typhus and role of serum osteopontin.

Authors:  Sang-Won Park; Chang-Seop Lee; Chi Kug Lee; Yee Gyung Kwak; Chisook Moon; Baek-Nam Kim; Eu Suk Kim; Jae Myung Kang; Myoung-don Oh
Journal:  Am J Trop Med Hyg       Date:  2011-11       Impact factor: 2.345

2.  Osteopontin impairs host defense during established gram-negative sepsis caused by Burkholderia pseudomallei (melioidosis).

Authors:  Gerritje J W van der Windt; W Joost Wiersinga; Catharina W Wieland; Ivo C S I Tjia; Nicholas P Day; Sharon J Peacock; Sandrine Florquin; Tom van der Poll
Journal:  PLoS Negl Trop Dis       Date:  2010-08-31

3.  Genes from Chagas susceptibility loci that are differentially expressed in T. cruzi-resistant mice are candidates accounting for impaired immunity.

Authors:  Sebastian E B Graefe; Thomas Streichert; Birgit S Budde; Peter Nürnberg; Christiane Steeg; Bertram Müller-Myhsok; Bernhard Fleischer
Journal:  PLoS One       Date:  2006-12-20       Impact factor: 3.240

4.  Osteopontin and malaria: no direct effect on parasite growth, but correlation with P. falciparum-specific B cells and BAFF in a malaria endemic area.

Authors:  Susanne E Mortazavi; Allan Lugaajju; Mark Kaddumukasa; Muyideen Kolapo Tijani; Fred Kironde; Kristina E M Persson
Journal:  BMC Microbiol       Date:  2021-11-06       Impact factor: 3.605
  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.