OBJECTIVE: To identify common variations in genes in the reverse cholesterol transport pathway with nongender-specific influence on plasma lipid and apolipoprotein levels. METHODS AND RESULTS: An average of 5 single nucleotide polymorphisms (SNPs) were genotyped within each of 45 genomic regions (54 genes) in blacks (1131 females and 812 males) and whites (1102 females and 954 males) from the Coronary Artery Risk Development in Young Adults (CARDIA) study. SNPs and gene-based 3-SNP haplotypes were evaluated for their ability to predict variation in plasma apolipoproteins (apo) A-I and apoB, total cholesterol (TC), high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and triglycerides (TG). We identified 14 SNPs in 6 candidate gene regions that explained statistically significant variation in the same trait in both genders of at least one race and with evidence of consistent genotype mean trend across gender within race. Haplotype analyses identified 9 candidate gene regions that explained statistically significant variation in one or both races. CONCLUSIONS: Four gene regions, ABCA1, APOA1/C3/A4/A5, APOE/C1/C4/C2, and CETP, explained plasma lipoprotein variation most consistently across strata. Other gene regions that influence plasma lipid and apolipoprotein levels within race include CYP7A1, LPL, PPARA, SOAT1, and SREBF2.
OBJECTIVE: To identify common variations in genes in the reverse cholesterol transport pathway with nongender-specific influence on plasma lipid and apolipoprotein levels. METHODS AND RESULTS: An average of 5 single nucleotide polymorphisms (SNPs) were genotyped within each of 45 genomic regions (54 genes) in blacks (1131 females and 812 males) and whites (1102 females and 954 males) from the Coronary Artery Risk Development in Young Adults (CARDIA) study. SNPs and gene-based 3-SNP haplotypes were evaluated for their ability to predict variation in plasma apolipoproteins (apo) A-I and apoB, total cholesterol (TC), high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and triglycerides (TG). We identified 14 SNPs in 6 candidate gene regions that explained statistically significant variation in the same trait in both genders of at least one race and with evidence of consistent genotype mean trend across gender within race. Haplotype analyses identified 9 candidate gene regions that explained statistically significant variation in one or both races. CONCLUSIONS: Four gene regions, ABCA1, APOA1/C3/A4/A5, APOE/C1/C4/C2, and CETP, explained plasma lipoprotein variation most consistently across strata. Other gene regions that influence plasma lipid and apolipoprotein levels within race include CYP7A1, LPL, PPARA, SOAT1, and SREBF2.
Authors: Danielle M Greenawalt; Radu Dobrin; Eugene Chudin; Ida J Hatoum; Christine Suver; John Beaulaurier; Bin Zhang; Victor Castro; Jun Zhu; Solveig K Sieberts; Susanna Wang; Cliona Molony; Steven B Heymsfield; Daniel M Kemp; Marc L Reitman; Pek Yee Lum; Eric E Schadt; Lee M Kaplan Journal: Genome Res Date: 2011-05-20 Impact factor: 9.043
Authors: María E Sáez; Antonio González-Pérez; María T Martínez-Larrad; Javier Gayán; Luis M Real; Manuel Serrano-Ríos; Agustín Ruiz Journal: BMC Med Genet Date: 2010-10-14 Impact factor: 2.103
Authors: Amanda K Golembesky; Marilie D Gammon; Kari E North; Jeannette T Bensen; Jane C Schroeder; Susan L Teitelbaum; Alfred I Neugut; Regina M Santella Journal: Carcinogenesis Date: 2008-06-26 Impact factor: 4.944
Authors: Jonathan Golledge; Erik Biros; Matthew Cooper; Nicole Warrington; Lyle J Palmer; Paul E Norman Journal: Atherosclerosis Date: 2009-09-25 Impact factor: 5.162
Authors: Kathy Klos; Lawrence Shimmin; Christie Ballantyne; Eric Boerwinkle; Andrew Clark; Josef Coresh; Craig Hanis; Kiang Liu; Scott Sayre; James Hixson Journal: Hum Mol Genet Date: 2008-03-31 Impact factor: 6.150
Authors: Robert R Graham; Chieko Kyogoku; Snaevar Sigurdsson; Irina A Vlasova; Leela R L Davies; Emily C Baechler; Robert M Plenge; Thearith Koeuth; Ward A Ortmann; Geoffrey Hom; Jason W Bauer; Clarence Gillett; Noel Burtt; Deborah S Cunninghame Graham; Robert Onofrio; Michelle Petri; Iva Gunnarsson; Elisabet Svenungsson; Lars Rönnblom; Gunnel Nordmark; Peter K Gregersen; Kathy Moser; Patrick M Gaffney; Lindsey A Criswell; Timothy J Vyse; Ann-Christine Syvänen; Paul R Bohjanen; Mark J Daly; Timothy W Behrens; David Altshuler Journal: Proc Natl Acad Sci U S A Date: 2007-04-05 Impact factor: 11.205