| Literature DB >> 16762563 |
JeanMarie Houghton1, Alexei Morozov, Iva Smirnova, Timothy C Wang.
Abstract
The cell of origin of cancer has been a strongly debated topic through out the history of cancer research. This review provides a historic framework and a synopsis of how the theories of cancer initiation and progression evolved from early times to the present day. We present the concept of a cancer stem cell, and review for you the literature supporting the existence of cancer stem cells in addition to a brief discussion on our own work supporting a bone marrow-derived source for the cancer stem cell, as well as cells of the cancer stroma.Entities:
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Year: 2006 PMID: 16762563 DOI: 10.1016/j.semcancer.2006.04.003
Source DB: PubMed Journal: Semin Cancer Biol ISSN: 1044-579X Impact factor: 15.707