| Literature DB >> 16762549 |
Brian Dyck1, Liren Zhao, Junko Tamiya, Joseph Pontillo, Sarah Hudson, Brett Ching, Christopher E Heise, Jenny Wen, Christi Norton, Ajay Madan, David Schwarz, Warren Wade, Val S Goodfellow.
Abstract
A series of substituted chromones were designed, synthesized, and evaluated for their ability to bind melanin-concentrating hormone receptor 1. Compounds with subnanomolar binding affinity and 66% oral bioavailability in rats were discovered.Entities:
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Year: 2006 PMID： 16762549 DOI： 10.1016/j.bmcl.2006.05.075
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823