BACKGROUND: Alcohol dependence (alcoholism) and major depressive disorder are frequently comorbid and are risk factors for suicidal behavior. Monoaminergic abnormalities have been implicated in the pathophysiology of depression, alcohol dependence, and suicidal behavior. Lower cerebrospinal fluid (CSF) 5-hydroxyindolacetic acid (5-HIAA) levels are associated with higher lethality of suicide attempts in major depression and predict a higher rate of future suicide. We sought to study the relationship of CSF monoamine metabolites to lethality of suicidal acts in depressed subjects with comorbid alcoholism. METHODS: We compared 16 high- and 16 low-lethality drug-free depressed suicide attempters with comorbid alcoholism. Subjects were free from any substance use disorder for at least two months. Demographic and clinical parameters, and CSF 5-HIAA, homovanillic acid (HVA), and 3-methoxy-4-hydroxyphenylglycol (MHPG) levels were examined. RESULTS: The two groups did not differ with regard to the demographic characteristics. CSF 5-HIAA levels were lower in high-lethality attempters compared to low-lethality attempters. There were no group difference in CSF HVA or MHPG levels. CONCLUSION: Higher lethality of suicidal behavior in depressed patients with alcoholism is related to lower serotonergic activity.
BACKGROUND:Alcohol dependence (alcoholism) and major depressive disorder are frequently comorbid and are risk factors for suicidal behavior. Monoaminergic abnormalities have been implicated in the pathophysiology of depression, alcohol dependence, and suicidal behavior. Lower cerebrospinal fluid (CSF) 5-hydroxyindolacetic acid (5-HIAA) levels are associated with higher lethality of suicide attempts in major depression and predict a higher rate of future suicide. We sought to study the relationship of CSF monoamine metabolites to lethality of suicidal acts in depressed subjects with comorbid alcoholism. METHODS: We compared 16 high- and 16 low-lethality drug-free depressed suicide attempters with comorbid alcoholism. Subjects were free from any substance use disorder for at least two months. Demographic and clinical parameters, and CSF 5-HIAA, homovanillic acid (HVA), and 3-methoxy-4-hydroxyphenylglycol (MHPG) levels were examined. RESULTS: The two groups did not differ with regard to the demographic characteristics. CSF 5-HIAA levels were lower in high-lethality attempters compared to low-lethality attempters. There were no group difference in CSF HVA or MHPG levels. CONCLUSION: Higher lethality of suicidal behavior in depressedpatients with alcoholism is related to lower serotonergic activity.
Authors: Leo Sher; Maria A Oquendo; Hanga C Galfalvy; Michael F Grunebaum; Ainsley K Burke; Gil Zalsman; J John Mann Journal: Addict Behav Date: 2004-12-29 Impact factor: 3.913
Authors: Maria A Oquendo; Hanga Galfalvy; Stefani Russo; Steven P Ellis; Michael F Grunebaum; Ainsley Burke; J John Mann Journal: Am J Psychiatry Date: 2004-08 Impact factor: 18.112
Authors: Leo Sher; Maria A Oquendo; Shuhua Li; Yung-yu Huang; Michael F Grunebaum; Ainsley K Burke; Kevin M Malone; J John Mann Journal: Neuropsychopharmacology Date: 2003-06-25 Impact factor: 7.853
Authors: Maurizio Pompili; Gianluca Serafini; Marco Innamorati; Giovanni Dominici; Stefano Ferracuti; Giorgio D Kotzalidis; Giulia Serra; Paolo Girardi; Luigi Janiri; Roberto Tatarelli; Leo Sher; David Lester Journal: Int J Environ Res Public Health Date: 2010-03-29 Impact factor: 3.390
Authors: Hanga Galfalvy; Dianne Currier; Maria A Oquendo; Gregory Sullivan; Yung-Yu Huang; J John Mann Journal: Int J Neuropsychopharmacol Date: 2009-07-02 Impact factor: 5.176