Literature DB >> 16762501

Nitric oxide regulates Angiopoietin1/Tie2 expression after stroke.

Alex Zacharek1, Jieli Chen, Chunling Zhang, Xu Cui, Cynthia Roberts, Hao Jiang, Hua Teng, Michael Chopp.   

Abstract

We tested whether the nitric oxide donor, (Z)-1-[N-(2-aminoethyl)-N-(2-ammonioethyl) aminio] diazen-1-ium-1,2-diolate (DETA-NONOate), increases expression of Angiopoietin (Ang1)/Tie2, which may play a role in regulating angiogenesis and vascular integrity after stroke in rats. Wistar rats were subjected to middle cerebral artery occlusion and treated with or without DETA-NONOate. Stroke rats treated with DETA-NONOate show significantly increased Ang1, Tie2 and Occludin expression in the ischemic border compared with control stroke animals (p < 0.05). Consistent with in vivo data, DETA-NONOate promotes capillary tube formation in cultured brain endothelial cells. Neutralizing Ang1 antibody attenuates DETA-NONOate-induced capillary tube formation. The data suggest that the Ang1/Tie2 axis promotes DETA-NONOate-induced angiogenesis and stabilizes of angiogenic vessels after stroke.

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Year:  2006        PMID： 16762501      PMCID： PMC2791334          DOI： 10.1016/j.neulet.2006.05.027

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  28 in total

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  19 in total

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