| Literature DB >> 16762381 |
Zhen-Dan He1, Cui-Ying Ma, Ghee Teng Tan, Kongmany Sydara, Pamela Tamez, Bounhoong Southavong, Somsanith Bouamanivong, D Doel Soejarto, John M Pezzuto, Harry H S Fong, Hong-Jie Zhang.
Abstract
Bioassay-directed fractionation of the antimalarial active CHCl(3) extract of the dried stems of Rourea minor (Gaertn.) Aubl. (Connaraceae) liana led to isolation of two glycosides, rourinoside (1) and rouremin (2), as well as five known compounds, 1-(26-hydroxyhexacosanoyl)-glycerol (3), 1-O-beta-D-glucopyranosyl-(2S,3R,4E-8Z)-2-N-(2'-hydroxypalmitoyl)-octadecasphinga-4,8-dienine, 9S,12S,13S-trihydroxy-10E-octadecenoic acid, dihydrovomifoliol-9-beta-D-glucopyranoside, and beta-sitosterol glucoside. Compounds 1-3 showed weak in vitro activities against Plasmodium falciparum. Their structures and stereochemistry were elucidated by spectroscopic methods and selected enzyme hydrolysis.Entities:
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Year: 2006 PMID： 16762381 DOI： 10.1016/j.phytochem.2006.04.012
Source DB: PubMed Journal: Phytochemistry ISSN： 0031-9422 Impact factor: 4.072