| Literature DB >> 16760794 |
Swati B Gupta1, Christopher T Mast, Nathan D Wolfe, Vlad Novitsky, Sheri A Dubey, Esper G Kallas, Mauro Schechter, Bernard Mbewe, Eftyhia Vardas, Punee Pitisuttithum, Donald Burke, Dan Freed, Robin Mogg, Paul M Coplan, Jon H Condra, Romnie S Long, Kiersten Anderson, Danilo R Casimiro, John W Shiver, Walter L Straus.
Abstract
An effective HIV type 1 (HIV-1) vaccine will likely require elicitation of broadly reactive cell-mediated immune (CMI) responses against divergent HIV-1 clades. We compared anti-HIV-1 T-cell immune responses among 363 unvaccinated adults infected with diverse HIV-1 clades. Response rates to clade B Gag and/or clade B Nef in Botswana (95%) and Cameroon (98%) were similar when compared with those in countries previously studied, including Brazil (92%), Thailand (96%), South Africa (96%), Malawi (100%), and the United States (100%). Substantial cross-clade cell-mediated immune responses in Botswana and Cameroon confirm previous findings in a larger, more genetically diverse collection of HIV-1 samples.Entities:
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Year: 2006 PMID： 16760794 DOI： 10.1097/01.qai.0000223017.01568.e7
Source DB: PubMed Journal: J Acquir Immune Defic Syndr ISSN： 1525-4135 Impact factor: 3.731