Literature DB >> 1676067

Effect of 8-methoxypsoralen in the dark on proliferation of stimulated lymphocytes.

G Górski1, H Antosz, A Gawron.   

Abstract

The effect of 8-methoxypsoralen (8-MOP) in the dark on proliferation of phytohaemagglutinin-stimulated human lymphocytes has been examined, using total blood leucocytes, the lymphocyte fraction and the T-lymphocyte subpopulation. 8-MOP (1 microgram mL-1) increased [3H]TdR incorporation and caused a rise in the blastic and mitotic index in all experimental cultures. The lymphocyte proliferation in these experiments was effected by a comitogenic effect of 8-MOP on T-lymphocytes.

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Year:  1991        PMID: 1676067     DOI: 10.1111/j.2042-7158.1991.tb05454.x

Source DB:  PubMed          Journal:  J Pharm Pharmacol        ISSN: 0022-3573            Impact factor:   3.765


  1 in total

1.  Stress response induced by DNA damage leads to specific, delayed and untargeted mutations.

Authors:  J J Boesen; S Stuivenberg; C H Thyssens; H Panneman; F Darroudi; P H Lohman; J W Simons
Journal:  Mol Gen Genet       Date:  1992-08
  1 in total

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