| Literature DB >> 16760646 |
Chiara Calatozzolo1, Emanuela Maderna, Bianca Pollo, Maurizio Gelati, Carlo Marras, Antonio Silvani, Danilo Croci, Amerigo Boiardi, Andrea Salmaggi.
Abstract
Both clinical and biological features have been reported as prognostic factors in low-grade gliomas. Among these, histotype, tumor size, enhancement, age and genetic pattern. Microvessel density (MVD) has been correlated to clinical outcome in astrocytomas, but its impact in oligodendrogliomas and mixed tumors is not sure. The pro-angiogenic chemokine stromal cell-derived factor (SDF-1/CXCL12) and its receptor CXC chemokine receptor 4 (CXCR4) have been described in low-grade gliomas, with a correlation between CXCL12 expression and shorter time to progression (TTP). The intermediate filament Nestin is expressed in proliferating vessels. Platelet-derived growth factor B (PDGF-B) and its receptor PDGFR-beta are also involved in angiogenesis and malignant progression in gliomas.Entities:
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Year: 2006 PMID： 16760646 DOI： 10.4161/cbt.5.7.2838
Source DB: PubMed Journal: Cancer Biol Ther ISSN： 1538-4047 Impact factor: 4.742