| Literature DB >> 16759768 |
Nicola P Klein1, Tyson H Holmes, Margaret A Sharp, Thomas C Heineman, Mark R Schleiss, David I Bernstein, George Kemble, Ann M Arvin, Cornelia L Dekker.
Abstract
Latent varicella zoster virus (VZV) can reactivate and cause zoster, the prevention of which relies upon cellular immunity to VZV. To assess temporal variation of VZV cell-mediated immunity in healthy naturally immune adults, we evaluated VZV-specific responder cell frequencies (RCF) longitudinally over 1 year in each of 25 adults. VZV-specific CD4+ T cells were detected (p < 0.003) and showed minimal variability in RCF. Additional analysis of VZV T cell RCF revealed differences between genders, with only males (p < 0.005) having detectable VZV-specific memory CD4+ T cell responses by this method. Taken together, results suggest that further studies regarding immunization of younger adults and females with the modified, high-potency live attenuated VZV vaccine may be warranted.Entities:
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Year: 2006 PMID： 16759768 DOI： 10.1016/j.vaccine.2006.04.060
Source DB: PubMed Journal: Vaccine ISSN： 0264-410X Impact factor: 3.641