AIM: To determine the influence of Type 1 diabetes mellitus on circulating adipocytokines in children. METHODS: The circulating concentrations of leptin, adiponectin, resistin and tumour necrosis factor (TNF)-alpha were measured in 91 children, aged 11.1 +/- 2.7 years, with Type 1 diabetes mellitus (T1DM). Ninety-one healthy children were selected as control subjects. RESULTS: Body mass index-adjusted leptin concentrations were higher in the pubertal diabetic children compared with the control children. There was a significant positive correlation between leptin and daily insulin dose in the diabetic group. Circulating adiponectin concentrations were higher in the prepubertal diabetic children and were positively associated with HbA(1c). Resistin concentrations were lower in the prepubertal non-diabetic subjects compared with the pubertal non-diabetic children, whose values were higher than those of the diabetic children. TNF-alpha concentrations were similar in non-diabetic and diabetic children. CONCLUSIONS: Circulating concentrations of adipocytokines are abnormal in Type 1 diabetic children, although the direction of change differs by cytokine. Pubertal development, in addition to insulin treatment and glycaemic control, also influences the concentrations.
AIM: To determine the influence of Type 1 diabetes mellitus on circulating adipocytokines in children. METHODS: The circulating concentrations of leptin, adiponectin, resistin and tumour necrosis factor (TNF)-alpha were measured in 91 children, aged 11.1 +/- 2.7 years, with Type 1 diabetes mellitus (T1DM). Ninety-one healthy children were selected as control subjects. RESULTS: Body mass index-adjusted leptin concentrations were higher in the pubertal diabeticchildren compared with the control children. There was a significant positive correlation between leptin and daily insulin dose in the diabetic group. Circulating adiponectin concentrations were higher in the prepubertal diabeticchildren and were positively associated with HbA(1c). Resistin concentrations were lower in the prepubertal non-diabetic subjects compared with the pubertal non-diabeticchildren, whose values were higher than those of the diabeticchildren. TNF-alpha concentrations were similar in non-diabetic and diabeticchildren. CONCLUSIONS: Circulating concentrations of adipocytokines are abnormal in Type 1 diabeticchildren, although the direction of change differs by cytokine. Pubertal development, in addition to insulin treatment and glycaemic control, also influences the concentrations.
Authors: David M Maahs; Richard F Hamman; Ralph D'Agostino; Lawrence M Dolan; Guiseppina Imperatore; Jean M Lawrence; Santica M Marcovina; Elizabeth J Mayer-Davis; Catherine Pihoker; Dana Dabelea Journal: J Pediatr Date: 2009-07 Impact factor: 4.406
Authors: Hanieh Yaghootkar; Claudia Lamina; Robert A Scott; Zari Dastani; Marie-France Hivert; Liling L Warren; Alena Stancáková; Sarah G Buxbaum; Leo-Pekka Lyytikäinen; Peter Henneman; Ying Wu; Chloe Y Y Cheung; James S Pankow; Anne U Jackson; Stefan Gustafsson; Jing Hua Zhao; Christie M Ballantyne; Weijia Xie; Richard N Bergman; Michael Boehnke; Fatiha el Bouazzaoui; Francis S Collins; Sandra H Dunn; Josee Dupuis; Nita G Forouhi; Christopher Gillson; Andrew T Hattersley; Jaeyoung Hong; Mika Kähönen; Johanna Kuusisto; Lyudmyla Kedenko; Florian Kronenberg; Alessandro Doria; Themistocles L Assimes; Ele Ferrannini; Torben Hansen; Ke Hao; Hans Häring; Joshua W Knowles; Cecilia M Lindgren; John J Nolan; Jussi Paananen; Oluf Pedersen; Thomas Quertermous; Ulf Smith; Terho Lehtimäki; Ching-Ti Liu; Ruth J F Loos; Mark I McCarthy; Andrew D Morris; Ramachandran S Vasan; Tim D Spector; Tanya M Teslovich; Jaakko Tuomilehto; Ko Willems van Dijk; Jorma S Viikari; Na Zhu; Claudia Langenberg; Erik Ingelsson; Robert K Semple; Alan R Sinaiko; Colin N A Palmer; Mark Walker; Karen S L Lam; Bernhard Paulweber; Karen L Mohlke; Cornelia van Duijn; Olli T Raitakari; Aurelian Bidulescu; Nick J Wareham; Markku Laakso; Dawn M Waterworth; Debbie A Lawlor; James B Meigs; J Brent Richards; Timothy M Frayling Journal: Diabetes Date: 2013-07-08 Impact factor: 9.461