Literature DB >> 1675911

MDMA: further evidence that its action in the medial prefrontal cortex is mediated by the serotonergic system.

H S Pan1, R Y Wang.   

Abstract

Systemically administered (+/-)-MDMA (3,4-methylenedioxymethamphetamine, 'Ecstasy') suppressed the firing rates of the majority of neurons in the medial prefrontal cortex (mPFc). The responses of mPFc cells to (+/-)-MDMA is mimicked by (+)-MDMA but not (-)-MDMA. Furthermore, pretreatment with fluoxetine (a specific 5-HT uptake blocker) but not GBR 12909 (a specific dopamine uptake blocker) prevented the suppressant action of MDMA. These data support the notion that the 5-HT system mediates (+/-)-MDMA's action.

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Year:  1991        PMID： 1675911     DOI： 10.1016/0006-8993(91)91640-m

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  4 in total

1.  Studies on the role of dopamine D1 receptors in the development and expression of MDMA-induced behavioral sensitization in rats.

Authors:  María Ramos; Beatriz Goñi-Allo; Norberto Aguirre
Journal:  Psychopharmacology (Berl)       Date:  2004-08-27       Impact factor: 4.530

Review 2.  The neurotrophic and neuroprotective effects of psychotropic agents.

Authors:  Joshua Hunsberger; Daniel R Austin; Ioline D Henter; Guang Chen
Journal:  Dialogues Clin Neurosci       Date:  2009       Impact factor: 5.986

3.  M.D.M.A. ("Ecstasy"); a case of possible drug-induced psychosis.

Authors:  H Williams; D Meagher; P Galligan
Journal:  Ir J Med Sci       Date:  1993-02       Impact factor: 1.568

4.  Locomotor stimulation produced by 3,4-methylenedioxymethamphetamine (MDMA) is correlated with dialysate levels of serotonin and dopamine in rat brain.

Authors:  Michael H Baumann; Robert D Clark; Richard B Rothman
Journal:  Pharmacol Biochem Behav       Date:  2008-03-04       Impact factor: 3.533
  4 in total

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