Literature DB >> 16759087

Dependence of molecular properties on proteomic family for marketed oral drugs.

Michal Vieth1, Jeffrey J Sutherland.   

Abstract

An association of drugs with their proteomic family reveals that molecular properties of drugs targeting proteases, lipid and peptide G-protein-coupled receptors (GPCRs), and nuclear hormone receptors significantly exceed limits for some properties in the "rule of five", while drugs targeting cytochrome P450s, biogenic amine GPCRs, and transporters have significantly lower values for certain properties. Also, the variation in drug targets appears to be a factor explaining increasing molecular weight over time.

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Year:  2006        PMID： 16759087     DOI： 10.1021/jm0603825

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  13 in total

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